FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136258977> ?p ?o ?g. }

• W3136258977 endingPage "S322" @default.
• W3136258977 startingPage "S321" @default.
• W3136258977 abstract "PurposeThe Lung Allocation Score (LAS) relies on the performance of two cox proportional hazards models that estimate waitlist and post-transplant survival. These models were developed using data from 2005-2008; it is unknown if they remain accurate.MethodsObservational cohort study of all lung transplant candidates and recipients greater than 12 years listed or transplanted between February, 19th 2015 to February, 19th 2019 in the Scientific Registry of Transplant Recipients database. We evaluated the discrimination of the waitlist and post-transplant models with the concordance probability estimate and the calibration of each model by comparing predicted versus observed one-year restricted mean survival times. We evaluated the overall accuracy of LAS by comparing a non-parametric estimate of the observed LAS with the actual LAS at transplant for each recipient percentile.ResultsDuring the study period, 11,539 eligible candidates were listed for transplant and 9,377 eligible recipients were transplanted. The waitlist model ranked candidates in the correct risk order 72% of the time (95% CI 71 - 73%) and underestimated survival by 59 days (95% CI 57 - 61 days) on average. The miscalibration increased from 6 days of error (95% CI 4 - 9 days) in the lowest risk decile to 136 days (95% CI 107-164 days) in the highest risk decile. The post-transplant model ranked recipients in the correct risk order 57% of the time (95% CI 55 - 58%) and underestimated post-transplant survival by 25 days (95% CI 23-27 days) on average. The miscalibration increased from 10 days of error in the lowest risk decile (95% CI 7 - 14 days) to 70 days (95% CI 64 - 77) in the highest risk decile. Overall, a recipient's LAS at transplant explained only 56% of variation in the observed LAS.ConclusionThe waitlist and the post-transplant models that form the backbone of LAS are inaccurate, limiting the ability of the system to rank candidates in the correct order. The LAS should be updated using a modern cohort patient cohort. The Lung Allocation Score (LAS) relies on the performance of two cox proportional hazards models that estimate waitlist and post-transplant survival. These models were developed using data from 2005-2008; it is unknown if they remain accurate. Observational cohort study of all lung transplant candidates and recipients greater than 12 years listed or transplanted between February, 19th 2015 to February, 19th 2019 in the Scientific Registry of Transplant Recipients database. We evaluated the discrimination of the waitlist and post-transplant models with the concordance probability estimate and the calibration of each model by comparing predicted versus observed one-year restricted mean survival times. We evaluated the overall accuracy of LAS by comparing a non-parametric estimate of the observed LAS with the actual LAS at transplant for each recipient percentile. During the study period, 11,539 eligible candidates were listed for transplant and 9,377 eligible recipients were transplanted. The waitlist model ranked candidates in the correct risk order 72% of the time (95% CI 71 - 73%) and underestimated survival by 59 days (95% CI 57 - 61 days) on average. The miscalibration increased from 6 days of error (95% CI 4 - 9 days) in the lowest risk decile to 136 days (95% CI 107-164 days) in the highest risk decile. The post-transplant model ranked recipients in the correct risk order 57% of the time (95% CI 55 - 58%) and underestimated post-transplant survival by 25 days (95% CI 23-27 days) on average. The miscalibration increased from 10 days of error in the lowest risk decile (95% CI 7 - 14 days) to 70 days (95% CI 64 - 77) in the highest risk decile. Overall, a recipient's LAS at transplant explained only 56% of variation in the observed LAS. The waitlist and the post-transplant models that form the backbone of LAS are inaccurate, limiting the ability of the system to rank candidates in the correct order. The LAS should be updated using a modern cohort patient cohort." @default.
• W3136258977 created "2021-03-29" @default.
• W3136258977 creator A5033124034 @default.
• W3136258977 creator A5035109877 @default.
• W3136258977 creator A5068868001 @default.
• W3136258977 creator A5078181499 @default.
• W3136258977 creator A5088547412 @default.
• W3136258977 date "2021-04-01" @default.
• W3136258977 modified "2023-09-26" @default.
• W3136258977 title "Assessing the Accuracy of the Lung Allocation Score" @default.
• W3136258977 cites W1972987731 @default.
• W3136258977 cites W1981084402 @default.
• W3136258977 cites W1984030023 @default.
• W3136258977 cites W1989149883 @default.
• W3136258977 cites W2015756047 @default.
• W3136258977 cites W2028356092 @default.
• W3136258977 cites W2065070755 @default.
• W3136258977 cites W2072013249 @default.
• W3136258977 cites W2109721294 @default.
• W3136258977 cites W2117897510 @default.
• W3136258977 cites W2120579447 @default.
• W3136258977 cites W2146759170 @default.
• W3136258977 cites W2155539729 @default.
• W3136258977 cites W2163885376 @default.
• W3136258977 cites W2169472056 @default.
• W3136258977 cites W2264767503 @default.
• W3136258977 cites W2280330931 @default.
• W3136258977 cites W2529436524 @default.
• W3136258977 cites W2532832586 @default.
• W3136258977 cites W2589951363 @default.
• W3136258977 cites W2594339954 @default.
• W3136258977 cites W2801755799 @default.
• W3136258977 cites W2908781846 @default.
• W3136258977 doi "https://doi.org/10.1016/j.healun.2021.01.908" @default.
• W3136258977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34802876" @default.
• W3136258977 hasPublicationYear "2021" @default.
• W3136258977 type Work @default.
• W3136258977 sameAs 3136258977 @default.
• W3136258977 citedByCount "4" @default.
• W3136258977 countsByYear W31362589772022 @default.
• W3136258977 countsByYear W31362589772023 @default.
• W3136258977 crossrefType "journal-article" @default.
• W3136258977 hasAuthorship W3136258977A5033124034 @default.
• W3136258977 hasAuthorship W3136258977A5035109877 @default.
• W3136258977 hasAuthorship W3136258977A5068868001 @default.
• W3136258977 hasAuthorship W3136258977A5078181499 @default.
• W3136258977 hasAuthorship W3136258977A5088547412 @default.
• W3136258977 hasBestOaLocation W31362589771 @default.
• W3136258977 hasConcept C105795698 @default.
• W3136258977 hasConcept C122048520 @default.
• W3136258977 hasConcept C126322002 @default.
• W3136258977 hasConcept C144024400 @default.
• W3136258977 hasConcept C147021879 @default.
• W3136258977 hasConcept C149923435 @default.
• W3136258977 hasConcept C160798450 @default.
• W3136258977 hasConcept C33923547 @default.
• W3136258977 hasConcept C50382708 @default.
• W3136258977 hasConcept C71924100 @default.
• W3136258977 hasConcept C72563966 @default.
• W3136258977 hasConceptScore W3136258977C105795698 @default.
• W3136258977 hasConceptScore W3136258977C122048520 @default.
• W3136258977 hasConceptScore W3136258977C126322002 @default.
• W3136258977 hasConceptScore W3136258977C144024400 @default.
• W3136258977 hasConceptScore W3136258977C147021879 @default.
• W3136258977 hasConceptScore W3136258977C149923435 @default.
• W3136258977 hasConceptScore W3136258977C160798450 @default.
• W3136258977 hasConceptScore W3136258977C33923547 @default.
• W3136258977 hasConceptScore W3136258977C50382708 @default.
• W3136258977 hasConceptScore W3136258977C71924100 @default.
• W3136258977 hasConceptScore W3136258977C72563966 @default.
• W3136258977 hasIssue "4" @default.
• W3136258977 hasLocation W31362589771 @default.
• W3136258977 hasOpenAccess W3136258977 @default.
• W3136258977 hasPrimaryLocation W31362589771 @default.
• W3136258977 hasRelatedWork W1605639367 @default.
• W3136258977 hasRelatedWork W2035682242 @default.
• W3136258977 hasRelatedWork W2071535500 @default.
• W3136258977 hasRelatedWork W2097266730 @default.
• W3136258977 hasRelatedWork W2119188509 @default.
• W3136258977 hasRelatedWork W2158039690 @default.
• W3136258977 hasRelatedWork W2164417576 @default.
• W3136258977 hasRelatedWork W2315085516 @default.
• W3136258977 hasRelatedWork W2603773853 @default.
• W3136258977 hasRelatedWork W3035478093 @default.
• W3136258977 hasVolume "40" @default.
• W3136258977 isParatext "false" @default.
• W3136258977 isRetracted "false" @default.
• W3136258977 magId "3136258977" @default.
• W3136258977 workType "article" @default.