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• W3136264517 abstract "Novel short-acting κ(kappa)-opioid receptor selective antagonists are translational tools to examine the impact of the κ-receptor/dynorphin system in assays related to central nervous system dysfunction (e.g., substance use disorders, anhedonia and depression). The effects of such compounds have been compared in males and females under very limited conditions.The goal of this study was to examine potential sex differences in the effects of a κ-agonist and a short-acting κ-antagonist in an ethologically relevant test of anhedonia, the splash test of self-grooming, and also in the forced swim test and in locomotor activity.We examined the dose-dependence of grooming deficits caused by the κ-agonist U50,488 (0.1-3.2 mg/kg intraperitoneal (i.p.)) in gonadally intact adult male and female C57BL/6J mice. We then compared the effects of the short-acting κ-antagonist LY2795050 ((3-chloro-4-(4-(((2S)-2-pyridin-3-ylpyrrolidin-1-yl)methyl) phenoxy)benzamide)); 0.032-0.1 mg/kg i.p.) in blocking grooming deficits caused by U50,488 (3.2 mg/kg). The effects of LY2795050 were also studied in the forced swim test (FST). The effects of LY2795050 in blocking the locomotor depressant effects of U50,488 (10 mg/kg) were also studied.U50,488 produced dose-dependent grooming deficits in male and female mice, and LY2795050 prevented these effects. In contrast, LY2795050 decreased immobility in the FST in males at a dose of 0.1 mg/kg, but not in females, up to a dose of 0.32 mg/kg. Also, LY2795050 (0.32 mg/kg) prevented and also reversed the locomotor-depressant effects of U50,488 (10 mg/kg), in males and females.This study further implicates the κ-receptor system in ethologically relevant aspects of anhedonia, and confirms sexual dimorphism in some behavioral effects of novel κ-antagonists." @default.
• W3136264517 created "2021-03-29" @default.
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• W3136264517 date "2021-03-26" @default.
• W3136264517 modified "2023-10-10" @default.
• W3136264517 title "Profile of a short-acting κ-antagonist, LY2795050, on self-grooming behaviors, forced swim test and locomotor activity: sex comparison in mice" @default.
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• W3136264517 cites W2014110722 @default.
• W3136264517 cites W2017876257 @default.
• W3136264517 cites W2025333158 @default.
• W3136264517 cites W2030260413 @default.
• W3136264517 cites W2039757611 @default.
• W3136264517 cites W2048763187 @default.
• W3136264517 cites W2049737322 @default.
• W3136264517 cites W2054092950 @default.
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• W3136264517 cites W2070703400 @default.
• W3136264517 cites W2070832275 @default.
• W3136264517 cites W2072955127 @default.
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• W3136264517 cites W2558151146 @default.
• W3136264517 cites W2568956974 @default.
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• W3136264517 doi "https://doi.org/10.1177/0269881121996883" @default.
• W3136264517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33769112" @default.
• W3136264517 hasPublicationYear "2021" @default.
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