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• W3136265144 abstract "Abstract Blister beetles have medicinal uses for their defensive secretion cantharidin, which has curative effects on many cancers and other diseases. It was demonstrated that sexual dimorphism exists in the production of cantharidin between male and female adults. This study performed a de novo assembly of Epicauta tibialis transcriptomes and analyzed the differentially expressed genes (DEGs) between male and female adults to help to find genes and pathways associated with cantharidin biosynthesis. A total of 99,295,624 paired reads were generated, and more than 7 Gb transcriptome data for each sample were obtained after trimming. The clean data were used to de novo assemble and then cluster into 27,355 unigenes, with a mean length of 1442 bp and an N50 of 2725 bp. Of these, 14,314 (52.33%) unigenes were annotated by protein databases. Differential expression analysis identified 284 differentially expressed genes (DEGs) between male and female adults. Nearly 239 DEGs were up‐regulated in male adults than in female adults, while 45 DEGs were down‐regulated. The Kyoto Encyclopedia of Gene and Genomes pathway enrichment manifested that seven up‐regulated DEGs in male adults were assigned to the terpenoid biosynthesis pathway, to which 19 unigenes were annotated. The DEGs in the terpenoid biosynthesis pathway between male and female adults may be responsible for the sexual dimorphism in cantharidin production. The up‐regulated genes assigned to the pathway in male adults may play a significant role in cantharidin biosynthesis, and its biosynthesis process is probably via the mevalonate pathway. The results would be helpful to better understand and reveal the complicated mechanism of the cantharidin biosynthesis." @default.
• W3136265144 created "2021-03-29" @default.
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• W3136265144 date "2021-03-15" @default.
• W3136265144 modified "2023-09-23" @default.
• W3136265144 title "De novo transcriptome assemblies of <i>Epicauta tibialis</i> provide insights into the sexual dimorphism in the production of cantharidin" @default.
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• W3136265144 doi "https://doi.org/10.1002/arch.21784" @default.
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