Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136270409> ?p ?o ?g. }
- W3136270409 abstract "Individuals with Down syndrome are genetically predisposed to developing acute megakaryoblastic leukemia. This myeloid leukemia associated with Down syndrome (ML–DS) demonstrates a model of step-wise leukemogenesis with perturbed hematopoiesis already presenting in utero , facilitating the acquisition of additional driver mutations such as truncating GATA1 variants, which are pathognomonic to the disease. Consequently, the affected individuals suffer from a transient abnormal myelopoiesis (TAM)—a pre-leukemic state preceding the progression to ML–DS. In our review, we focus on the molecular mechanisms of the different steps of clonal evolution in Down syndrome leukemogenesis, and aim to provide a comprehensive view on the complex interplay between gene dosage imbalances, GATA1 mutations and somatic mutations affecting JAK-STAT signaling, the cohesin complex and epigenetic regulators." @default.
- W3136270409 created "2021-03-29" @default.
- W3136270409 creator A5030406251 @default.
- W3136270409 creator A5058777381 @default.
- W3136270409 creator A5078774471 @default.
- W3136270409 date "2021-03-11" @default.
- W3136270409 modified "2023-09-27" @default.
- W3136270409 title "Molecular Mechanisms of the Genetic Predisposition to Acute Megakaryoblastic Leukemia in Infants With Down Syndrome" @default.
- W3136270409 cites W1517297797 @default.
- W3136270409 cites W1557839603 @default.
- W3136270409 cites W1569503463 @default.
- W3136270409 cites W1613319667 @default.
- W3136270409 cites W1860217789 @default.
- W3136270409 cites W1914798032 @default.
- W3136270409 cites W1964683842 @default.
- W3136270409 cites W1964716733 @default.
- W3136270409 cites W1969012158 @default.
- W3136270409 cites W1973670358 @default.
- W3136270409 cites W1974957584 @default.
- W3136270409 cites W1976386009 @default.
- W3136270409 cites W1976397332 @default.
- W3136270409 cites W1976993315 @default.
- W3136270409 cites W1980706177 @default.
- W3136270409 cites W1981081447 @default.
- W3136270409 cites W1981460612 @default.
- W3136270409 cites W1981683426 @default.
- W3136270409 cites W1983631422 @default.
- W3136270409 cites W1989391941 @default.
- W3136270409 cites W1991401817 @default.
- W3136270409 cites W1991766825 @default.
- W3136270409 cites W1992470811 @default.
- W3136270409 cites W1992621257 @default.
- W3136270409 cites W1996602797 @default.
- W3136270409 cites W1998602132 @default.
- W3136270409 cites W2001388611 @default.
- W3136270409 cites W2002214947 @default.
- W3136270409 cites W2005388260 @default.
- W3136270409 cites W2008297559 @default.
- W3136270409 cites W2008312111 @default.
- W3136270409 cites W2013226712 @default.
- W3136270409 cites W2013238087 @default.
- W3136270409 cites W2018973123 @default.
- W3136270409 cites W2024748833 @default.
- W3136270409 cites W2025220707 @default.
- W3136270409 cites W2027036934 @default.
- W3136270409 cites W2032175419 @default.
- W3136270409 cites W2032649896 @default.
- W3136270409 cites W2033577964 @default.
- W3136270409 cites W2035175374 @default.
- W3136270409 cites W2035992944 @default.
- W3136270409 cites W2036312135 @default.
- W3136270409 cites W2036712153 @default.
- W3136270409 cites W2036755058 @default.
- W3136270409 cites W2037870786 @default.
- W3136270409 cites W2039766781 @default.
- W3136270409 cites W2039842713 @default.
- W3136270409 cites W2040812277 @default.
- W3136270409 cites W2041393796 @default.
- W3136270409 cites W2042916026 @default.
- W3136270409 cites W2045568306 @default.
- W3136270409 cites W2045832625 @default.
- W3136270409 cites W2046286855 @default.
- W3136270409 cites W2049869441 @default.
- W3136270409 cites W2051255515 @default.
- W3136270409 cites W2051540384 @default.
- W3136270409 cites W2051544387 @default.
- W3136270409 cites W2052208292 @default.
- W3136270409 cites W2052972273 @default.
- W3136270409 cites W2053132428 @default.
- W3136270409 cites W2054338068 @default.
- W3136270409 cites W2054752568 @default.
- W3136270409 cites W2056227778 @default.
- W3136270409 cites W2056446394 @default.
- W3136270409 cites W2056771226 @default.
- W3136270409 cites W2063556118 @default.
- W3136270409 cites W2063636969 @default.
- W3136270409 cites W2066020792 @default.
- W3136270409 cites W2067110557 @default.
- W3136270409 cites W2067986039 @default.
- W3136270409 cites W2068232821 @default.
- W3136270409 cites W2070028842 @default.
- W3136270409 cites W2070839797 @default.
- W3136270409 cites W2071050300 @default.
- W3136270409 cites W2073580835 @default.
- W3136270409 cites W2073724558 @default.
- W3136270409 cites W2073983388 @default.
- W3136270409 cites W2074122556 @default.
- W3136270409 cites W2074378056 @default.
- W3136270409 cites W2075621261 @default.
- W3136270409 cites W2076076392 @default.
- W3136270409 cites W2078157614 @default.
- W3136270409 cites W2079864519 @default.
- W3136270409 cites W2080033371 @default.
- W3136270409 cites W2080791129 @default.
- W3136270409 cites W2081144551 @default.
- W3136270409 cites W2084522917 @default.
- W3136270409 cites W2085033687 @default.
- W3136270409 cites W2085790004 @default.
- W3136270409 cites W2088264073 @default.
- W3136270409 cites W2089019735 @default.