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- W3136272093 abstract "Abstract In eukaryotes, chromatin binding to the inner nuclear membrane (INM) and nuclear pore complexes (NPCs) contributes to spatial organization of the genome and epigenetic programs important for gene expression. In mitosis, chromatin-nuclear envelope (NE) interactions are lost and then formed again as sister chromosomes segregate to post-mitotic nuclei. Investigating these processes in S. cerevisiae , we identified temporally and spatially controlled phosphorylation-dependent SUMOylation events that positively regulate post-metaphase chromatin association with the NE. Our work establishes a phosphorylation-mediated targeting mechanism of the SUMO ligase Siz2 to the INM during anaphase, where Siz2 binds to and SUMOylates the VAP protein Scs2. The recruitment of Siz2 through Scs2 is further responsible for a wave of SUMOylation along the INM that supports the assembly and anchorage of subtelomeric chromatin at the INM and localization of an active gene ( INO1 ) to NPCs during the later stages of mitosis and into G1-phase." @default.
- W3136272093 created "2021-03-29" @default.
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- W3136272093 date "2021-03-24" @default.
- W3136272093 modified "2023-10-16" @default.
- W3136272093 title "Phosphorylation-dependent mitotic SUMOylation drives nuclear envelope-chromatin interactions" @default.
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- W3136272093 doi "https://doi.org/10.1101/2021.03.24.436817" @default.
- W3136272093 hasPublicationYear "2021" @default.
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