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• W3136272166 abstract "Previous studies report that first pregnancy is associated with persistent decreases in HDL-cholesterol (HDL-C) concentrations.This study evaluated factors associated with declines in HDL-C concentration in parous and nulliparous young women.This study leverages data from African-American and white women from the NHLBI Growth and Health Study. Parity-related changes in lipids, BMI and percent body fat were assessed longitudinally. A subset of primiparous and nulliparous women with paired lipid measurements were analyzed regarding changes in HDL-C concentrations.Among 870 women in longitudinal analyses, African-American women had higher parity (p<0.0001), with baseline measurements of each parity group being similar. HDL-C concentration decreased significantly and remained lower after the first pregnancy, while BMI and percent body fat increased with increasing parity. In the subset of 401 women, HDL-C concentration decreased among primiparous women (-4.81 ± 0.93 mg/dl), with no overall change in nulliparous (p = 0.003). In both groups, greater HDL-C concentration declines were independently associated with higher initial HDL-C concentration and greater increases in BMI (both p<0.0001). Among primiparous women, younger delivery age (p = 0.0001) and birth control use (p = 0.004) were associated with greater HDL-C concentration decline. Nulliparous white women's HDL-C concentration increased over time, with no change in African-American women (p = 0.008); no racial difference was seen in primiparous women.Persistent decreases in HDL-C concentration were associated with the first pregnancy, and were greater with higher initial HDL-C concentration. Racial differences in HDL-C concentration emerged over time in nulliparous women, but not primiparous women. Potential impacts of these findings on women's long-term cardiometabolic health should be evaluated." @default.
• W3136272166 created "2021-03-29" @default.
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• W3136272166 date "2021-05-01" @default.
• W3136272166 modified "2023-09-24" @default.
• W3136272166 title "Longitudinal changes in HDL-cholesterol concentration are associated with different risk factors in primiparous and nulliparous young women: The NHLBI Growth and Health Study (NGHS)" @default.
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• W3136272166 doi "https://doi.org/10.1016/j.jacl.2021.03.004" @default.
• W3136272166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33875403" @default.
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