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- W3136275020 endingPage "3016" @default.
- W3136275020 startingPage "2998" @default.
- W3136275020 abstract "Chronic urticaria (CU) is a chronic inflammatory mast cell-driven disorder. Endothelial cells (ECs) contribute importantly to key features of CU. Several markers of EC (dys)function in CU have been reported, but have not yet been systematically reviewed. In this study, we systematically reviewed and categorized all published markers of EC functions in CU through a comprehensive search in Pubmed, The Cochrane Library, Web of Science, and SCOPUS using the following Mesh terms: CU AND pathogenesis AND (vasculopathy OR microangiopathy OR ECs OR marker). In total, 79 articles were selected and the identified biomarkers were categorized according to EC (dys)function in CU. The most frequent and consistently reported upregulated biomarkers in CU skin were adhesion molecules, TF, and P-selectin. The most frequently reported upregulated and reliable biomarkers in sera of CU patients were F1+2 for coagulation cascade involvement, D-dimers for fibrinolysis, and MMP-9 for vascular permeability. Emerging biomarkers described in the selected articles were endostatin, heat shock proteins, cleaved high molecular weight kininogen, and adipokines. This systematic review contributes to the pool of growing evidence for vascular involvement in CU where EC dysfunction is present in different aspects of cell survival, maintenance of vascular structure, and coagulation/fibrinolysis balance." @default.
- W3136275020 created "2021-03-29" @default.
- W3136275020 creator A5004923168 @default.
- W3136275020 creator A5043990764 @default.
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- W3136275020 creator A5083930310 @default.
- W3136275020 creator A5087466441 @default.
- W3136275020 creator A5091156366 @default.
- W3136275020 date "2021-04-25" @default.
- W3136275020 modified "2023-10-17" @default.
- W3136275020 title "Markers for the involvement of endothelial cells and the coagulation system in chronic urticaria: A systematic review" @default.
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