Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136275452> ?p ?o ?g. }
- W3136275452 endingPage "e214302" @default.
- W3136275452 startingPage "e214302" @default.
- W3136275452 abstract "Accumulating evidence suggests that children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more likely to manifest mild symptoms and are at a lower risk of developing severe respiratory disease compared with adults. It remains unknown how the immune response in children differs from that of adolescents and adults.To investigate the association of age with the quantity and quality of SARS-CoV-2 antibody responses.This cross-sectional study used 31 426 SARS-CoV-2 antibody test results from pediatric and adult patients. Data were collected from a New York City hospital from April 9 to August 31, 2020. The semiquantitative immunoglobin (Ig) G levels were compared between 85 pediatric and 3648 adult patients. Further analysis of SARS-CoV-2 antibody profiles was performed on sera from 126 patients aged 1 to 24 years.SARS-CoV-2 antibody positivity rates and IgG levels were evaluated in patients from a wide range of age groups (1-102 years). SARS-CoV-2 IgG level, total antibody (TAb) level, surrogate neutralizing antibody (SNAb) activity, and antibody binding avidity were compared between children (aged 1-10 years), adolescents (aged 11-18 years), and young adults (aged 19-24 years).Among 31 426 antibody test results (19 797 [63.0%] female patients), with 1194 pediatric patients (mean [SD] age, 11.0 [5.3] years) and 30 232 adult patients (mean [SD] age, 49.2 [17.1] years), the seroprevalence in the pediatric (197 [16.5%; 95% CI, 14.4%-18.7%]) and adult (5630 [18.6%; 95% CI, 18.2%-19.1%]) patient populations was similar. The SARS-CoV-2 IgG level showed a negative correlation with age in the pediatric population (r = -0.45, P < .001) and a moderate but positive correlation with age in adults (r = 0.24, P < .001). Patients aged 19 to 30 years exhibited the lowest IgG levels (eg, aged 25-30 years vs 1-10 years: 99 [44-180] relative fluorescence units [RFU] vs 443 [188-851] RFU). In the subset cohort aged 1 to 24 years, IgG, TAb, SNAb and avidity were negatively correlated with age (eg, IgG: r = -0.51; P < .001). Children exhibited higher median (IQR) IgG levels, TAb levels, and SNAb activity compared with adolescents (eg, IgG levels: 473 [233-656] RFU vs 191 [82-349] RFU; P < .001) and young adults (eg, IgG levels: 473 [233-656] RFU vs 85 [38-150] RFU; P < .001). Adolescents also exhibited higher median (IQR) TAb levels, IgG levels, and SNAb activity than young adults (eg, TAb levels: 961 [290-2074] RFU vs 370 [125-697]; P = .006). In addition, children had higher antibody binding avidity compared with young adults, but the difference was not significant.The results of this study suggest that SARS-CoV-2 viral specific antibody response profiles are distinct in different age groups. Age-targeted strategies for disease screening and management as well as vaccine development may be warranted." @default.
- W3136275452 created "2021-03-29" @default.
- W3136275452 creator A5009054572 @default.
- W3136275452 creator A5010045617 @default.
- W3136275452 creator A5010916893 @default.
- W3136275452 creator A5019680032 @default.
- W3136275452 creator A5022391631 @default.
- W3136275452 creator A5034671606 @default.
- W3136275452 creator A5044638985 @default.
- W3136275452 creator A5049285773 @default.
- W3136275452 creator A5049410296 @default.
- W3136275452 creator A5064702056 @default.
- W3136275452 creator A5066222316 @default.
- W3136275452 creator A5074016400 @default.
- W3136275452 creator A5080585906 @default.
- W3136275452 creator A5089684804 @default.
- W3136275452 date "2021-03-22" @default.
- W3136275452 modified "2023-10-09" @default.
- W3136275452 title "Association of Age With SARS-CoV-2 Antibody Response" @default.
- W3136275452 cites W1593105372 @default.
- W3136275452 cites W3007859670 @default.
- W3136275452 cites W3008028633 @default.
- W3136275452 cites W3010819577 @default.
- W3136275452 cites W3011307261 @default.
- W3136275452 cites W3012797451 @default.
- W3136275452 cites W3016469463 @default.
- W3136275452 cites W3025210114 @default.
- W3136275452 cites W3033900878 @default.
- W3136275452 cites W3034016318 @default.
- W3136275452 cites W3035938488 @default.
- W3136275452 cites W3038003713 @default.
- W3136275452 cites W3080997493 @default.
- W3136275452 cites W3086119226 @default.
- W3136275452 cites W3090936981 @default.
- W3136275452 cites W3092141513 @default.
- W3136275452 cites W3096205573 @default.
- W3136275452 cites W3121526741 @default.
- W3136275452 cites W3124562652 @default.
- W3136275452 cites W3128383622 @default.
- W3136275452 cites W3129005328 @default.
- W3136275452 cites W4239341636 @default.
- W3136275452 doi "https://doi.org/10.1001/jamanetworkopen.2021.4302" @default.
- W3136275452 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7985726" @default.
- W3136275452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33749770" @default.
- W3136275452 hasPublicationYear "2021" @default.
- W3136275452 type Work @default.
- W3136275452 sameAs 3136275452 @default.
- W3136275452 citedByCount "136" @default.
- W3136275452 countsByYear W31362754522021 @default.
- W3136275452 countsByYear W31362754522022 @default.
- W3136275452 countsByYear W31362754522023 @default.
- W3136275452 crossrefType "journal-article" @default.
- W3136275452 hasAuthorship W3136275452A5009054572 @default.
- W3136275452 hasAuthorship W3136275452A5010045617 @default.
- W3136275452 hasAuthorship W3136275452A5010916893 @default.
- W3136275452 hasAuthorship W3136275452A5019680032 @default.
- W3136275452 hasAuthorship W3136275452A5022391631 @default.
- W3136275452 hasAuthorship W3136275452A5034671606 @default.
- W3136275452 hasAuthorship W3136275452A5044638985 @default.
- W3136275452 hasAuthorship W3136275452A5049285773 @default.
- W3136275452 hasAuthorship W3136275452A5049410296 @default.
- W3136275452 hasAuthorship W3136275452A5064702056 @default.
- W3136275452 hasAuthorship W3136275452A5066222316 @default.
- W3136275452 hasAuthorship W3136275452A5074016400 @default.
- W3136275452 hasAuthorship W3136275452A5080585906 @default.
- W3136275452 hasAuthorship W3136275452A5089684804 @default.
- W3136275452 hasBestOaLocation W31362754521 @default.
- W3136275452 hasConcept C126322002 @default.
- W3136275452 hasConcept C159654299 @default.
- W3136275452 hasConcept C179223381 @default.
- W3136275452 hasConcept C187212893 @default.
- W3136275452 hasConcept C203014093 @default.
- W3136275452 hasConcept C205545832 @default.
- W3136275452 hasConcept C2778494684 @default.
- W3136275452 hasConcept C2779134260 @default.
- W3136275452 hasConcept C3007834351 @default.
- W3136275452 hasConcept C3008058167 @default.
- W3136275452 hasConcept C45189115 @default.
- W3136275452 hasConcept C524204448 @default.
- W3136275452 hasConcept C71924100 @default.
- W3136275452 hasConceptScore W3136275452C126322002 @default.
- W3136275452 hasConceptScore W3136275452C159654299 @default.
- W3136275452 hasConceptScore W3136275452C179223381 @default.
- W3136275452 hasConceptScore W3136275452C187212893 @default.
- W3136275452 hasConceptScore W3136275452C203014093 @default.
- W3136275452 hasConceptScore W3136275452C205545832 @default.
- W3136275452 hasConceptScore W3136275452C2778494684 @default.
- W3136275452 hasConceptScore W3136275452C2779134260 @default.
- W3136275452 hasConceptScore W3136275452C3007834351 @default.
- W3136275452 hasConceptScore W3136275452C3008058167 @default.
- W3136275452 hasConceptScore W3136275452C45189115 @default.
- W3136275452 hasConceptScore W3136275452C524204448 @default.
- W3136275452 hasConceptScore W3136275452C71924100 @default.
- W3136275452 hasIssue "3" @default.
- W3136275452 hasLocation W31362754521 @default.
- W3136275452 hasLocation W31362754522 @default.
- W3136275452 hasLocation W31362754523 @default.
- W3136275452 hasOpenAccess W3136275452 @default.