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- W3136276216 abstract "Background: RAD51 from the cluster genes which have a vital role in the pathogenesis of squamous cell carcinoma. Present study aimed to analysed polymorphisms of RAD5 single nucleotide 1(rs2619679, rs2928140 and rs1801320) and their relationship to breast cancer (BC) and ovarian cancer (OC) in Iraqi population. Methods: This study included, 35 females with BC, 35 females with OC, who were diagnostic histopathologicaly, and 30 healthy females as control. Three SNPs (rs2619679, rs2928140 and rs1801320) of RAD51 were selected for genotyping by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: Statistically differences were found in the distribution of AA and TT genotypes and A/T alleles for rs2619679 in BC (p0.05) between BC and control but mutant genotype GG and mutant allele G appeared in highest frequency (42%, 57%) in BC. Statistically changes of RAD51 SNPs for OC were found in the incidence of AA and T alleles for rs2619679 (p0.05) between OC and control but mutant genotype GG and mutant allele G appeared in OC with highest rate (45%, 59%). Mutant genotype/allele of rs2619679 (TT/T), rs2928140(CC/C) and rs1801320 (GG/G) appeared as effective factors for cancer with acceptable rate for diagnosis of BC and OC. Conclusion: mutation in RAD51 SNPs (rs2619679, rs2928140 , rs1801320) associated with increases the possibility of BC and OC." @default.
- W3136276216 created "2021-03-29" @default.
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- W3136276216 date "2020-01-01" @default.
- W3136276216 modified "2023-09-23" @default.
- W3136276216 title "Germline Mutation of RAD51 Single Nucleotide Polymorphisms as Susceptibility Factor for Breast and Ovarian Cancer" @default.
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