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- W3136277558 abstract "• The discussed ABT-546 drug preparation is improved method includes alteration in the synthetic strategy for increasing the overall yield of the drug and enantioselecty with efficient purification technique. The catalytic, extremely effective enantioselective conjugate-addition strategy was approved by via 4 mol% of bis(oxazoline)-Mg(OTf) 2 along with amine complex as co-catalyst. The magnicium triflate based catalysis afford 88% selectivity in the molecule and provide less dependence on the tartrate salt for enantioselectivity, which was previously prepared for attaining chiral purity for the synthesis of the endothelin-A antagonist ABT-546 . Along with enantioselective conjugate-addition the new strategy involves green solvents in the final steps of ABT-546 drug preparation. The use of green solvent owes its own advantage of minimizing the residues remaining in the API synthesized. The article includes the case study of the ABT-546 to discuss the green chemistry objectives fulfilled by pharma industry." @default.
- W3136277558 created "2021-03-29" @default.
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- W3136277558 date "2022-01-01" @default.
- W3136277558 modified "2023-09-23" @default.
- W3136277558 title "Development of industrial efficient asymmetric synthesis of endothelin-A antagonist ABT-546: A case study based on green chemistry perspective" @default.
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- W3136277558 doi "https://doi.org/10.1016/j.matpr.2021.02.584" @default.
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