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• W3136278968 endingPage "129252" @default.
• W3136278968 startingPage "129252" @default.
• W3136278968 abstract "This study aims to engineer a novel developed superabsorbent (NDS) as potent hemostatic agent. NDS induces coagulation process due to the high adhesion affinity to the wet tissue, high swelling ratio and clotting potency. NDS controls massive bleedings by inducing the red blood cells accumulation, platelets aggregation and fibrin network formation at the site of bleeding. • NDS acts as brilliant superabsorbent that absorb 60 g of blood per one g of NDS. • NDS as a powerful hemostatic agents activated coagulation cascade process. • Biochemical, hematological, and pathological results didn’t show toxic effects. Engineering of effective and biocompatible hemostatic materials to control massive bleeding is one of the interesting research fields. Herein, cellulose-based polymer modified by silica aerogel and calcium chloride was used for suitable control of bleeding. Novel developed superabsorbent (NDS) was synthesized by chemical and physical cross-linking methods. NDS not only quickly absorbs a high amount of blood component (60 g/g), but it can also adhere strongly (~90 KPa) to damaged tissue. The contributions of the freeze-drying method and presence of silica aerogel as structural modifiers led to the creation of a superabsorbent with a porosity percentage of 70% which creates a significant ability to absorb blood cells. NDS negative surface charge and presence of silica nanoparticles and calcium ions accelerate activation of the coagulation cascade process. Superior hemostatic ability of NDS compared to commercial hemostatic powder (Gelita-Cel® and Traumastem®) was proved by complementary tests such as blood absorption content, RBC attachment, blood clotting index (BCI), platelet adhesion, clotting time test and partial thromboplastin time (PTT). In vivo study results demonstrate that the NDS could successfully decrease bleeding time and blood loss amount in Wistar rat’s cut-out femoral artery, 2.25 and 4.3 fold better than Gelita-Cel® and 2.13 and 4.4 fold better than Traumastem®. NDS biodegradability was proved by its implantation inside the Wistar rat's body during 14 days. Biochemical, hematological, and pathological tests did not show inflammation and toxic effects in the liver and renal tissues, skin tissues, and alteration in complete blood count parameters (CBC) in NDS treated Wistar rats. In conclusion, the cellulose-based NDS hemostatic biomaterial is suggested for future clinical trial studies due to its powerful ability in bleeding control." @default.
• W3136278968 created "2021-03-29" @default.
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• W3136278968 date "2021-08-01" @default.
• W3136278968 modified "2023-10-13" @default.
• W3136278968 title "Biodegradable cellulose-based superabsorbent as potent hemostatic agent" @default.
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• W3136278968 doi "https://doi.org/10.1016/j.cej.2021.129252" @default.
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