Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136282903> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W3136282903 endingPage "2398" @default.
- W3136282903 startingPage "2391" @default.
- W3136282903 abstract "Safety biomarkers are important drug development tools, both preclinically and clinically. It is a straightforward process to correlate the performance of nonclinical safety biomarkers with histopathology, and ideally, the biomarker is useful in all species commonly used in safety assessment. In clinical validation studies, where histopathology is not feasible, safety biomarkers are compared to the response of standard biomarkers and/or to clinical adjudication. Worldwide, regulatory agencies have put in place processes to qualify biomarkers to provide confidence in the manner of use and interpretation of biomarker data in drug development studies. This paper describes currently qualified safety biomarkers which can be utilized to monitor for nephrotoxicity and cardiotoxicity and ongoing projects to qualify safety biomarkers for liver, skeletal muscle, and vascular injury. In many cases, the development and use of these critical drug development tools is dependent upon partnerships and the precompetitive sharing of data to support qualification efforts." @default.
- W3136282903 created "2021-03-29" @default.
- W3136282903 creator A5023833134 @default.
- W3136282903 creator A5088120714 @default.
- W3136282903 date "2021-03-23" @default.
- W3136282903 modified "2023-09-27" @default.
- W3136282903 title "Qualification of translational safety biomarkers" @default.
- W3136282903 cites W1583137789 @default.
- W3136282903 cites W1971719161 @default.
- W3136282903 cites W2059655597 @default.
- W3136282903 cites W2112144522 @default.
- W3136282903 cites W2768386871 @default.
- W3136282903 cites W2884927432 @default.
- W3136282903 cites W3039580108 @default.
- W3136282903 cites W3046848805 @default.
- W3136282903 cites W3048104387 @default.
- W3136282903 doi "https://doi.org/10.1177/15353702211002153" @default.
- W3136282903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8606956" @default.
- W3136282903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33757340" @default.
- W3136282903 hasPublicationYear "2021" @default.
- W3136282903 type Work @default.
- W3136282903 sameAs 3136282903 @default.
- W3136282903 citedByCount "2" @default.
- W3136282903 countsByYear W31362829032023 @default.
- W3136282903 crossrefType "journal-article" @default.
- W3136282903 hasAuthorship W3136282903A5023833134 @default.
- W3136282903 hasAuthorship W3136282903A5088120714 @default.
- W3136282903 hasBestOaLocation W31362829031 @default.
- W3136282903 hasConcept C104317684 @default.
- W3136282903 hasConcept C124535831 @default.
- W3136282903 hasConcept C126322002 @default.
- W3136282903 hasConcept C142724271 @default.
- W3136282903 hasConcept C177713679 @default.
- W3136282903 hasConcept C2776694085 @default.
- W3136282903 hasConcept C2778233292 @default.
- W3136282903 hasConcept C2780035454 @default.
- W3136282903 hasConcept C2781197716 @default.
- W3136282903 hasConcept C46111723 @default.
- W3136282903 hasConcept C535046627 @default.
- W3136282903 hasConcept C55493867 @default.
- W3136282903 hasConcept C60644358 @default.
- W3136282903 hasConcept C64903051 @default.
- W3136282903 hasConcept C71924100 @default.
- W3136282903 hasConcept C86803240 @default.
- W3136282903 hasConcept C98274493 @default.
- W3136282903 hasConceptScore W3136282903C104317684 @default.
- W3136282903 hasConceptScore W3136282903C124535831 @default.
- W3136282903 hasConceptScore W3136282903C126322002 @default.
- W3136282903 hasConceptScore W3136282903C142724271 @default.
- W3136282903 hasConceptScore W3136282903C177713679 @default.
- W3136282903 hasConceptScore W3136282903C2776694085 @default.
- W3136282903 hasConceptScore W3136282903C2778233292 @default.
- W3136282903 hasConceptScore W3136282903C2780035454 @default.
- W3136282903 hasConceptScore W3136282903C2781197716 @default.
- W3136282903 hasConceptScore W3136282903C46111723 @default.
- W3136282903 hasConceptScore W3136282903C535046627 @default.
- W3136282903 hasConceptScore W3136282903C55493867 @default.
- W3136282903 hasConceptScore W3136282903C60644358 @default.
- W3136282903 hasConceptScore W3136282903C64903051 @default.
- W3136282903 hasConceptScore W3136282903C71924100 @default.
- W3136282903 hasConceptScore W3136282903C86803240 @default.
- W3136282903 hasConceptScore W3136282903C98274493 @default.
- W3136282903 hasFunder F4320332163 @default.
- W3136282903 hasIssue "22" @default.
- W3136282903 hasLocation W31362829031 @default.
- W3136282903 hasLocation W31362829032 @default.
- W3136282903 hasLocation W31362829033 @default.
- W3136282903 hasOpenAccess W3136282903 @default.
- W3136282903 hasPrimaryLocation W31362829031 @default.
- W3136282903 hasRelatedWork W105877818 @default.
- W3136282903 hasRelatedWork W1756140406 @default.
- W3136282903 hasRelatedWork W2101312806 @default.
- W3136282903 hasRelatedWork W2114281628 @default.
- W3136282903 hasRelatedWork W2372770165 @default.
- W3136282903 hasRelatedWork W2507716202 @default.
- W3136282903 hasRelatedWork W2804573260 @default.
- W3136282903 hasRelatedWork W2936512011 @default.
- W3136282903 hasRelatedWork W3090916670 @default.
- W3136282903 hasRelatedWork W4285797485 @default.
- W3136282903 hasVolume "246" @default.
- W3136282903 isParatext "false" @default.
- W3136282903 isRetracted "false" @default.
- W3136282903 magId "3136282903" @default.
- W3136282903 workType "article" @default.