Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136285183> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W3136285183 abstract "Author(s): Najdahmadi, Avid | Advisor(s): Botvinick, Elliot L | Abstract: In Type 1 Diabetes, insulin producing cells are destroyed by the immune system, resulting in unchecked glycemic conditions. Different approaches including tissue engineering and continuous analyte monitoring hold promise in providing insulin independence and glycemic control. Tissue engineering aims to transplant and protect pancreatic islets, cells responsible for secretion of insulin. One strategy is to encapsulate the islets inside alginate hydrogels. The encapsulant provides passage to glucose, nutrients and the secreted insulin, while blocking the passage of antibodies. In this study, confocal microscopy is used to study diffusional characteristics of alginate. This approach can quantitatively analyze the structural changes after exposure to physiological conditions. Using this strategy can potentially tune the structure prior to implantation to account for the upcoming in vivo changes. Another approach is to place the islets inside subcutaneous medical devices. Such devices can provide protection to the cells, however due to hypoxic conditions transplanted cells can lose function. In this study vascularization of different types of polymer devices is studied. Oxygen sensitive tubes were fabricated and placed inside devices prior to subcutaneous implantation in nude mice. Using a non-invasive optical technology oxygen partial pressure within the devices is monitored. This technology aims to create a quantitative metric to assess the state of vascularization and readiness of devices for cell insertion. Another promising technology for diabetes management and achievement of tight glycemic control is continuous analyte monitoring. In this technique, different analytes such as glucose and lactate can be continuously measured. The data collected can be used to create a mathematical algorithm that can predict upcoming glycemic changes and in conjunction with an insulin pump can automatically administer insulin. In this work, a new composite material is invented that can accommodate necessary components to detect and report the changes of analyte levels in physiological conditions. This material can be used to create different types of continuous biosensors. Importantly this composite material shows success in preserving sensitivity and activity of biosensors for long periods of storage, it shows fast responses to changes of analyte concentrations and is manufacturable in very small geometries aimed for painless insertion." @default.
- W3136285183 created "2021-03-29" @default.
- W3136285183 creator A5035384318 @default.
- W3136285183 date "2018-01-01" @default.
- W3136285183 modified "2023-09-27" @default.
- W3136285183 title "Tissue Engineering and Biosensing, Towards Cure and Control of Diabetes" @default.
- W3136285183 hasPublicationYear "2018" @default.
- W3136285183 type Work @default.
- W3136285183 sameAs 3136285183 @default.
- W3136285183 citedByCount "0" @default.
- W3136285183 crossrefType "journal-article" @default.
- W3136285183 hasAuthorship W3136285183A5035384318 @default.
- W3136285183 hasConcept C10390740 @default.
- W3136285183 hasConcept C126322002 @default.
- W3136285183 hasConcept C134018914 @default.
- W3136285183 hasConcept C136229726 @default.
- W3136285183 hasConcept C165220095 @default.
- W3136285183 hasConcept C171250308 @default.
- W3136285183 hasConcept C185592680 @default.
- W3136285183 hasConcept C192562407 @default.
- W3136285183 hasConcept C2779306644 @default.
- W3136285183 hasConcept C2780353609 @default.
- W3136285183 hasConcept C2780473172 @default.
- W3136285183 hasConcept C2781232474 @default.
- W3136285183 hasConcept C2911091166 @default.
- W3136285183 hasConcept C41008148 @default.
- W3136285183 hasConcept C43617362 @default.
- W3136285183 hasConcept C49892992 @default.
- W3136285183 hasConcept C555293320 @default.
- W3136285183 hasConcept C71924100 @default.
- W3136285183 hasConceptScore W3136285183C10390740 @default.
- W3136285183 hasConceptScore W3136285183C126322002 @default.
- W3136285183 hasConceptScore W3136285183C134018914 @default.
- W3136285183 hasConceptScore W3136285183C136229726 @default.
- W3136285183 hasConceptScore W3136285183C165220095 @default.
- W3136285183 hasConceptScore W3136285183C171250308 @default.
- W3136285183 hasConceptScore W3136285183C185592680 @default.
- W3136285183 hasConceptScore W3136285183C192562407 @default.
- W3136285183 hasConceptScore W3136285183C2779306644 @default.
- W3136285183 hasConceptScore W3136285183C2780353609 @default.
- W3136285183 hasConceptScore W3136285183C2780473172 @default.
- W3136285183 hasConceptScore W3136285183C2781232474 @default.
- W3136285183 hasConceptScore W3136285183C2911091166 @default.
- W3136285183 hasConceptScore W3136285183C41008148 @default.
- W3136285183 hasConceptScore W3136285183C43617362 @default.
- W3136285183 hasConceptScore W3136285183C49892992 @default.
- W3136285183 hasConceptScore W3136285183C555293320 @default.
- W3136285183 hasConceptScore W3136285183C71924100 @default.
- W3136285183 hasLocation W31362851831 @default.
- W3136285183 hasOpenAccess W3136285183 @default.
- W3136285183 hasPrimaryLocation W31362851831 @default.
- W3136285183 hasRelatedWork W123242137 @default.
- W3136285183 hasRelatedWork W165596071 @default.
- W3136285183 hasRelatedWork W2062083499 @default.
- W3136285183 hasRelatedWork W2112634765 @default.
- W3136285183 hasRelatedWork W2124082567 @default.
- W3136285183 hasRelatedWork W2612139229 @default.
- W3136285183 hasRelatedWork W2757650562 @default.
- W3136285183 hasRelatedWork W2769509715 @default.
- W3136285183 hasRelatedWork W2899885705 @default.
- W3136285183 hasRelatedWork W2901880308 @default.
- W3136285183 hasRelatedWork W2938362547 @default.
- W3136285183 hasRelatedWork W2948652216 @default.
- W3136285183 hasRelatedWork W2991343834 @default.
- W3136285183 hasRelatedWork W3153870269 @default.
- W3136285183 hasRelatedWork W3206037480 @default.
- W3136285183 hasRelatedWork W2930096984 @default.
- W3136285183 isParatext "false" @default.
- W3136285183 isRetracted "false" @default.
- W3136285183 magId "3136285183" @default.
- W3136285183 workType "article" @default.