Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136285762> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W3136285762 endingPage "228" @default.
- W3136285762 startingPage "218" @default.
- W3136285762 abstract "PURPOSE This study initially explored the expression of GDF-15 in gallbladder carcinoma and its clinical significance, and analyzed the correlation between the expression of GDF-15 and the clinicopathological features as well as the prognosis of patients with gallbladder carcinoma. METHODS Enzyme-linked immunosorbent assay (ELISA) was used to determine the expression of GDF-15 in the serum of 42 patients with gallbladder cancer. The control group included 24 patients with cholecystitis and 20 healthy volunteers. The immunohistochemical method (IHC) was used to detect the expression of GDF-15 in 42 cases of gallbladder tumor tissue and 35 cases of adjacent non-tumor gallbladder tissue specimens. RESULTS The results of ELISA showed that the concentration of GDF-15 in serum was considerably higher in gallbladder cancer patients than that in gallbladder benign lesions and healthy volunteers (p=0.006, p<0.001). In the group of patients with gallbladder cancer, the consistence of GDF-15 in patients with lymph node metastasis was significantly higher than that of patients without lymph node metastasis (p<0.001). Immunohistochemical staining showed that the expression of GDF-15 in gallbladder carcinoma was markedly higher than that in non-tumor gallbladder tissues (p=0.003), and the high expression of GDF-15 was significantly correlated with the differentiation grade of gallbladder carcinoma and tumor TNM stage (p=0.005, p=0.002). CONCLUSION GDF-15 is related to the occurrence and development of gallbladder cancer. GDF-15 in serum can be used as a potential marker for the diagnosis of gallbladder cancer and can be used to predict the lymph node metastasis of gallbladder cancer." @default.
- W3136285762 created "2021-03-29" @default.
- W3136285762 creator A5011123221 @default.
- W3136285762 creator A5025753743 @default.
- W3136285762 creator A5065122971 @default.
- W3136285762 creator A5070251041 @default.
- W3136285762 creator A5072193931 @default.
- W3136285762 creator A5087402397 @default.
- W3136285762 date "2021-01-01" @default.
- W3136285762 modified "2023-09-23" @default.
- W3136285762 title "The expression of growth differentiation factor 15 in gallbladder carcinoma." @default.
- W3136285762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33721455" @default.
- W3136285762 hasPublicationYear "2021" @default.
- W3136285762 type Work @default.
- W3136285762 sameAs 3136285762 @default.
- W3136285762 citedByCount "1" @default.
- W3136285762 countsByYear W31362857622022 @default.
- W3136285762 crossrefType "journal-article" @default.
- W3136285762 hasAuthorship W3136285762A5011123221 @default.
- W3136285762 hasAuthorship W3136285762A5025753743 @default.
- W3136285762 hasAuthorship W3136285762A5065122971 @default.
- W3136285762 hasAuthorship W3136285762A5070251041 @default.
- W3136285762 hasAuthorship W3136285762A5072193931 @default.
- W3136285762 hasAuthorship W3136285762A5087402397 @default.
- W3136285762 hasConcept C121608353 @default.
- W3136285762 hasConcept C126322002 @default.
- W3136285762 hasConcept C142724271 @default.
- W3136285762 hasConcept C146357865 @default.
- W3136285762 hasConcept C151730666 @default.
- W3136285762 hasConcept C204232928 @default.
- W3136285762 hasConcept C2776534502 @default.
- W3136285762 hasConcept C2777148285 @default.
- W3136285762 hasConcept C2777546739 @default.
- W3136285762 hasConcept C2779013556 @default.
- W3136285762 hasConcept C71924100 @default.
- W3136285762 hasConcept C86803240 @default.
- W3136285762 hasConcept C90924648 @default.
- W3136285762 hasConceptScore W3136285762C121608353 @default.
- W3136285762 hasConceptScore W3136285762C126322002 @default.
- W3136285762 hasConceptScore W3136285762C142724271 @default.
- W3136285762 hasConceptScore W3136285762C146357865 @default.
- W3136285762 hasConceptScore W3136285762C151730666 @default.
- W3136285762 hasConceptScore W3136285762C204232928 @default.
- W3136285762 hasConceptScore W3136285762C2776534502 @default.
- W3136285762 hasConceptScore W3136285762C2777148285 @default.
- W3136285762 hasConceptScore W3136285762C2777546739 @default.
- W3136285762 hasConceptScore W3136285762C2779013556 @default.
- W3136285762 hasConceptScore W3136285762C71924100 @default.
- W3136285762 hasConceptScore W3136285762C86803240 @default.
- W3136285762 hasConceptScore W3136285762C90924648 @default.
- W3136285762 hasIssue "1" @default.
- W3136285762 hasOpenAccess W3136285762 @default.
- W3136285762 hasRelatedWork W1646985209 @default.
- W3136285762 hasRelatedWork W1963781069 @default.
- W3136285762 hasRelatedWork W2044675475 @default.
- W3136285762 hasRelatedWork W2070884133 @default.
- W3136285762 hasRelatedWork W2325780756 @default.
- W3136285762 hasRelatedWork W2350142616 @default.
- W3136285762 hasRelatedWork W2353767158 @default.
- W3136285762 hasRelatedWork W2359958350 @default.
- W3136285762 hasRelatedWork W2368247057 @default.
- W3136285762 hasRelatedWork W2370500087 @default.
- W3136285762 hasRelatedWork W2371238908 @default.
- W3136285762 hasRelatedWork W2372628402 @default.
- W3136285762 hasRelatedWork W2377064280 @default.
- W3136285762 hasRelatedWork W2380890005 @default.
- W3136285762 hasRelatedWork W2382123780 @default.
- W3136285762 hasRelatedWork W2394134920 @default.
- W3136285762 hasRelatedWork W2523301414 @default.
- W3136285762 hasRelatedWork W2888304939 @default.
- W3136285762 hasRelatedWork W2970713069 @default.
- W3136285762 hasRelatedWork W969467840 @default.
- W3136285762 hasVolume "26" @default.
- W3136285762 isParatext "false" @default.
- W3136285762 isRetracted "false" @default.
- W3136285762 magId "3136285762" @default.
- W3136285762 workType "article" @default.