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• W3136289028 abstract "In an Alport mouse model of heart failure with preserved ejection fraction (HFpEF), exercise and carvedilol synergistically improved systolic function without affecting diastole. Carvedilol alone or in combination with exercise also improved kidney function. Molecular analyses indicate that the observed improvements in cardiorenal functions were mediated at least in part by effects on serum osteopontin and related inflammatory cytokine cascades. The work presents new potential therapeutic targets and approaches for HFpEF." @default.
• W3136289028 created "2021-03-29" @default.
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• W3136289028 date "2021-05-01" @default.
• W3136289028 modified "2023-10-18" @default.
• W3136289028 title "Carvedilol and exercise combination therapy improves systolic but not diastolic function and reduces plasma osteopontin in <i>Col4a3^−/−</i> Alport mice" @default.
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• W3136289028 doi "https://doi.org/10.1152/ajpheart.00535.2020" @default.
• W3136289028 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8163658" @default.
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