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- W3136292496 startingPage "1849" @default.
- W3136292496 abstract "Abstract Significant progress has laid the groundwork in understanding the fundamental role of catalase enzyme and catalase‐like nanozymes, notably with the emergence of nano‐bioreactors which are promoting nanomaterials‐based antitumor therapeutic strategies. The radiotherapy techniques such as photodynamic, photothermal, photoacoustic and along with chemotherapy are extensively used for interrupting microenvironment by exerting to locally applied ionizing‐radiations. Nevertheless, tumor therapy not only deficient in therapeutic efficiency for various solid tumors but also alerts significant side effects. The convergence of nano‐bioreactor driven catalase delivery at the lysosome of tumor cells with photodynamic therapy (PDT) tool along with the engineered catalase‐like nanozymes enable outstanding efficacy of radiotherapy for in vivo target specific cell population. Herein, the state of the art of catalase delivering nano‐bioreactors that activate the catalase delivery in tumor microenvironment (TME) are reviewed. This was linked with the functional mimic catalase‐like engineered nanozymes for improving the challenges in the TME for a wide‐range of cell lines in vivo. Such nanoarchitecture‐based strategies of catalase and synthetic nanozymes include lysosomal upregulation of H 2 O 2 in TME, image‐based probing, and mechanism of catalase action for reactive oxygen species generation which are likely to amplify efficiency of cancer therapy." @default.
- W3136292496 created "2021-03-29" @default.
- W3136292496 creator A5047184744 @default.
- W3136292496 creator A5077709942 @default.
- W3136292496 date "2021-03-16" @default.
- W3136292496 modified "2023-10-04" @default.
- W3136292496 title "Biocompatible nanoreactors of catalase and nanozymes for anticancer therapeutics" @default.
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