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- W3136296168 abstract "Antibiotic resistance represents one of the biggest public health challenges in the last few years. Mur ligases (MurC–MurF) are involved in the synthesis of UDP-N-acetylmuramyl-pentapeptide, the main building block of bacterial peptidoglycan polymer. They are essential for the survival of bacteria and therefore important antibacterial targets. We report herein the synthesis and structure–activity relationships of Mur ligases inhibitors with an azastilbene scaffold. Several compounds showed promising inhibitory potencies against multiple ligases and one compound also possessed moderate antibacterial activity. These results represent a solid ground for further development and optimization of structurally novel antimicrobial agents to combat the rising bacterial resistance." @default.
- W3136296168 created "2021-03-29" @default.
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- W3136296168 date "2021-05-01" @default.
- W3136296168 modified "2023-10-18" @default.
- W3136296168 title "Mur ligases inhibitors with azastilbene scaffold: Expanding the structure–activity relationship" @default.
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- W3136296168 doi "https://doi.org/10.1016/j.bmcl.2021.127966" @default.
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