FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136297652> ?p ?o ?g. }

• W3136297652 abstract "Globally, there are over 200 million cases of malaria annually and over 400,000 deaths. Early and accurate detection of low-density parasitaemia and asymptomatic individuals is key to achieving the World Health Organization (WHO) 2030 sustainable development goals of reducing malaria-related deaths by 90% and eradication in 35 countries. Current rapid diagnostic tests are neither sensitive nor specific enough to detect the low parasite concentrations in the blood of asymptomatic individuals.Here, an imaging-based sensing technique, particle diffusometry (PD), is combined with loop mediated isothermal amplification (LAMP) on a smartphone-enabled device to detect low levels of parasitaemia often associated with asymptomatic malaria. After amplification, PD quantifies the Brownian motion of fluorescent nanoparticles in the solution during a 30 s video taken on the phone. The resulting diffusion coefficient is used to detect the presence of Plasmodium DNA amplicons. The coefficients of known negative samples are compared to positive samples using a one-way ANOVA post-hoc Dunnett's test for confirmation of amplification.As few as 3 parasite/µL of blood was detectable in 45 min without DNA extraction. Plasmodium falciparum parasites were detected from asymptomatic individuals' whole blood samples with 89% sensitivity and 100% specificity when compared to quantitative polymerase chain reaction (qPCR).PD-LAMP is of value for the detection of low density parasitaemia especially in areas where trained personnel may be scarce. The demonstration of this smartphone biosensor paired with the sensitivity of LAMP provides a proof of concept to achieve widespread asymptomatic malaria testing at the point of care." @default.
• W3136297652 created "2021-03-29" @default.
• W3136297652 creator A5018590318 @default.
• W3136297652 creator A5028703159 @default.
• W3136297652 creator A5044643029 @default.
• W3136297652 creator A5045510458 @default.
• W3136297652 creator A5053899113 @default.
• W3136297652 creator A5055742599 @default.
• W3136297652 creator A5073284312 @default.
• W3136297652 creator A5077758719 @default.
• W3136297652 creator A5080230857 @default.
• W3136297652 date "2021-09-25" @default.
• W3136297652 modified "2023-10-15" @default.
• W3136297652 title "Towards the use of a smartphone imaging-based tool for point-of-care detection of asymptomatic low-density malaria parasitaemia" @default.
• W3136297652 cites W1888099230 @default.
• W3136297652 cites W1966459680 @default.
• W3136297652 cites W1971179465 @default.
• W3136297652 cites W1975565305 @default.
• W3136297652 cites W1975801865 @default.
• W3136297652 cites W1980207903 @default.
• W3136297652 cites W1981843126 @default.
• W3136297652 cites W1989477602 @default.
• W3136297652 cites W199510873 @default.
• W3136297652 cites W1995792964 @default.
• W3136297652 cites W2003741250 @default.
• W3136297652 cites W2005886497 @default.
• W3136297652 cites W2019851585 @default.
• W3136297652 cites W2023978991 @default.
• W3136297652 cites W2031222215 @default.
• W3136297652 cites W2038081624 @default.
• W3136297652 cites W2057876450 @default.
• W3136297652 cites W2061375735 @default.
• W3136297652 cites W2078557912 @default.
• W3136297652 cites W2083865189 @default.
• W3136297652 cites W2091490176 @default.
• W3136297652 cites W2108579383 @default.
• W3136297652 cites W2108891327 @default.
• W3136297652 cites W2115837962 @default.
• W3136297652 cites W2122562099 @default.
• W3136297652 cites W2124946580 @default.
• W3136297652 cites W2136738350 @default.
• W3136297652 cites W2138505818 @default.
• W3136297652 cites W2144162688 @default.
• W3136297652 cites W2144165280 @default.
• W3136297652 cites W2151373350 @default.
• W3136297652 cites W2182980689 @default.
• W3136297652 cites W2263084061 @default.
• W3136297652 cites W2263670471 @default.
• W3136297652 cites W2266475816 @default.
• W3136297652 cites W2292338687 @default.
• W3136297652 cites W2523419623 @default.
• W3136297652 cites W2579529461 @default.
• W3136297652 cites W2602965957 @default.
• W3136297652 cites W2744528576 @default.
• W3136297652 cites W2745718653 @default.
• W3136297652 cites W2766991821 @default.
• W3136297652 cites W2768139112 @default.
• W3136297652 cites W2804639808 @default.
• W3136297652 cites W2884703312 @default.
• W3136297652 cites W2916501589 @default.
• W3136297652 cites W2922347438 @default.
• W3136297652 cites W2924169488 @default.
• W3136297652 cites W2954187936 @default.
• W3136297652 cites W2970769387 @default.
• W3136297652 cites W2974154864 @default.
• W3136297652 cites W3036894645 @default.
• W3136297652 cites W3036951478 @default.
• W3136297652 cites W3048112850 @default.
• W3136297652 cites W3063151860 @default.
• W3136297652 cites W4247026907 @default.
• W3136297652 doi "https://doi.org/10.1186/s12936-021-03894-w" @default.
• W3136297652 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8466697" @default.
• W3136297652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34563189" @default.
• W3136297652 hasPublicationYear "2021" @default.
• W3136297652 type Work @default.
• W3136297652 sameAs 3136297652 @default.
• W3136297652 citedByCount "7" @default.
• W3136297652 countsByYear W31362976522022 @default.
• W3136297652 countsByYear W31362976522023 @default.
• W3136297652 crossrefType "journal-article" @default.
• W3136297652 hasAuthorship W3136297652A5018590318 @default.
• W3136297652 hasAuthorship W3136297652A5028703159 @default.
• W3136297652 hasAuthorship W3136297652A5044643029 @default.
• W3136297652 hasAuthorship W3136297652A5045510458 @default.
• W3136297652 hasAuthorship W3136297652A5053899113 @default.
• W3136297652 hasAuthorship W3136297652A5055742599 @default.
• W3136297652 hasAuthorship W3136297652A5073284312 @default.
• W3136297652 hasAuthorship W3136297652A5077758719 @default.
• W3136297652 hasAuthorship W3136297652A5080230857 @default.
• W3136297652 hasBestOaLocation W31362976521 @default.
• W3136297652 hasConcept C104317684 @default.
• W3136297652 hasConcept C126322002 @default.
• W3136297652 hasConcept C142724271 @default.
• W3136297652 hasConcept C159047783 @default.
• W3136297652 hasConcept C190612196 @default.
• W3136297652 hasConcept C203014093 @default.
• W3136297652 hasConcept C2777910003 @default.
• W3136297652 hasConcept C2778048844 @default.
• W3136297652 hasConcept C2778371730 @default.
• W3136297652 hasConcept C2780261877 @default.

• next