FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136298828> ?p ?o ?g. }

• W3136298828 abstract "Abstract Obsessive-compulsive disorder (OCD) is a chronic and severe psychiatric disorder for which effective treatment options are limited. Structural and functional neuroimaging studies have consistently implicated the orbitofrontal cortex (OFC) and striatum in the pathophysiology of the disorder. Recent genetic evidence points to involvement of components of the excitatory synapse in the etiology of OCD. However, the transcriptional alterations that could link genetic risk to known structural and functional abnormalities remain mostly unknown. To assess potential transcriptional changes in the OFC and two striatal regions (caudate nucleus and nucleus accumbens) of OCD subjects relative to unaffected comparison subjects, we sequenced messenger RNA transcripts from these brain regions. In a joint analysis of all three regions, 904 transcripts were differentially expressed between 7 OCD versus 8 unaffected comparison subjects. Region-specific analyses highlighted a smaller number of differences, which concentrated in caudate and nucleus accumbens. Pathway analyses of the 904 differentially expressed transcripts showed enrichment for genes involved in synaptic signaling, with these synapse-associated genes displaying lower expression in OCD subjects relative to unaffected comparison subjects. Finally, we estimated that cell type fractions of medium spiny neurons were lower whereas vascular cells and astrocyte fractions were higher in tissue of OCD subjects. Together, these data provide the first unbiased examination of differentially expressed transcripts in both OFC and striatum of OCD subjects. These transcripts encoded synaptic proteins more often than expected by chance, and thus implicate the synapse as a vulnerable molecular compartment for OCD." @default.
• W3136298828 created "2021-03-29" @default.
• W3136298828 creator A5005460474 @default.
• W3136298828 creator A5021301519 @default.
• W3136298828 creator A5036942871 @default.
• W3136298828 creator A5042915991 @default.
• W3136298828 creator A5047091057 @default.
• W3136298828 creator A5056174368 @default.
• W3136298828 creator A5068330330 @default.
• W3136298828 creator A5068997529 @default.
• W3136298828 creator A5079509060 @default.
• W3136298828 date "2021-03-15" @default.
• W3136298828 modified "2023-10-14" @default.
• W3136298828 title "Transcriptome alterations are enriched for synapse-associated genes in the striatum of subjects with obsessive-compulsive disorder" @default.
• W3136298828 cites W1462915242 @default.
• W3136298828 cites W149276057 @default.
• W3136298828 cites W1507778097 @default.
• W3136298828 cites W1586270996 @default.
• W3136298828 cites W1804880984 @default.
• W3136298828 cites W1914669721 @default.
• W3136298828 cites W1951724000 @default.
• W3136298828 cites W1969353942 @default.
• W3136298828 cites W1973748621 @default.
• W3136298828 cites W1979292526 @default.
• W3136298828 cites W1980377083 @default.
• W3136298828 cites W1985399534 @default.
• W3136298828 cites W1998622616 @default.
• W3136298828 cites W2003956812 @default.
• W3136298828 cites W2007417768 @default.
• W3136298828 cites W2010457001 @default.
• W3136298828 cites W2012440798 @default.
• W3136298828 cites W2013041188 @default.
• W3136298828 cites W2014564921 @default.
• W3136298828 cites W2016927879 @default.
• W3136298828 cites W2018235826 @default.
• W3136298828 cites W2023317991 @default.
• W3136298828 cites W2033549747 @default.
• W3136298828 cites W2038460348 @default.
• W3136298828 cites W2040187632 @default.
• W3136298828 cites W2045983513 @default.
• W3136298828 cites W2047576371 @default.
• W3136298828 cites W2077016065 @default.
• W3136298828 cites W2077164692 @default.
• W3136298828 cites W2078966869 @default.
• W3136298828 cites W2080914771 @default.
• W3136298828 cites W2084388248 @default.
• W3136298828 cites W2096107166 @default.
• W3136298828 cites W2097386588 @default.
• W3136298828 cites W2098915263 @default.
• W3136298828 cites W2100825937 @default.
• W3136298828 cites W2105548486 @default.
• W3136298828 cites W2105697752 @default.
• W3136298828 cites W2109125813 @default.
• W3136298828 cites W2111396411 @default.
• W3136298828 cites W2120599193 @default.
• W3136298828 cites W2121343862 @default.
• W3136298828 cites W2130410032 @default.
• W3136298828 cites W2133781551 @default.
• W3136298828 cites W2142150505 @default.
• W3136298828 cites W2152416379 @default.
• W3136298828 cites W2152962921 @default.
• W3136298828 cites W2154076220 @default.
• W3136298828 cites W2158033629 @default.
• W3136298828 cites W2160619276 @default.
• W3136298828 cites W2160683465 @default.
• W3136298828 cites W2170634352 @default.
• W3136298828 cites W2462597493 @default.
• W3136298828 cites W2526546796 @default.
• W3136298828 cites W2739834351 @default.
• W3136298828 cites W2889033116 @default.
• W3136298828 cites W2906213364 @default.
• W3136298828 cites W2906276550 @default.
• W3136298828 cites W2912901595 @default.
• W3136298828 cites W2917182736 @default.
• W3136298828 cites W2948046056 @default.
• W3136298828 cites W2967063345 @default.
• W3136298828 cites W3023504226 @default.
• W3136298828 cites W3026796704 @default.
• W3136298828 cites W37113994 @default.
• W3136298828 cites W4211038581 @default.
• W3136298828 doi "https://doi.org/10.1038/s41398-021-01290-1" @default.
• W3136298828 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7961029" @default.
• W3136298828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33723209" @default.
• W3136298828 hasPublicationYear "2021" @default.
• W3136298828 type Work @default.
• W3136298828 sameAs 3136298828 @default.
• W3136298828 citedByCount "6" @default.
• W3136298828 countsByYear W31362988282021 @default.
• W3136298828 countsByYear W31362988282022 @default.
• W3136298828 countsByYear W31362988282023 @default.
• W3136298828 crossrefType "journal-article" @default.
• W3136298828 hasAuthorship W3136298828A5005460474 @default.
• W3136298828 hasAuthorship W3136298828A5021301519 @default.
• W3136298828 hasAuthorship W3136298828A5036942871 @default.
• W3136298828 hasAuthorship W3136298828A5042915991 @default.
• W3136298828 hasAuthorship W3136298828A5047091057 @default.
• W3136298828 hasAuthorship W3136298828A5056174368 @default.
• W3136298828 hasAuthorship W3136298828A5068330330 @default.
• W3136298828 hasAuthorship W3136298828A5068997529 @default.
• W3136298828 hasAuthorship W3136298828A5079509060 @default.

• next