Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136298903> ?p ?o ?g. }
- W3136298903 endingPage "105055" @default.
- W3136298903 startingPage "105055" @default.
- W3136298903 abstract "The current emergency of the novel coronavirus SARS-CoV2 urged the need for broad-spectrum antiviral drugs as the first line of treatment. Coronaviruses are a large family of viruses that already challenged humanity in at least two other previous outbreaks and are likely to be a constant threat for the future. In this work we developed a pipeline based on in silico docking of known drugs on SARS-CoV1/2 RNA-dependent RNA polymerase combined with in vitro antiviral assays on both SARS-CoV2 and the common cold human coronavirus HCoV-OC43. Results showed that certain drugs displayed activity for both viruses at a similar inhibitory concentration, while others were specific. In particular, the antipsychotic drug lurasidone and the antiviral drug elbasvir showed promising activity in the low micromolar range against both viruses with good selectivity index." @default.
- W3136298903 created "2021-03-29" @default.
- W3136298903 creator A5013706096 @default.
- W3136298903 creator A5020364767 @default.
- W3136298903 creator A5026529883 @default.
- W3136298903 creator A5034485871 @default.
- W3136298903 creator A5034854833 @default.
- W3136298903 creator A5055712810 @default.
- W3136298903 creator A5056221917 @default.
- W3136298903 creator A5057063089 @default.
- W3136298903 creator A5066081837 @default.
- W3136298903 date "2021-05-01" @default.
- W3136298903 modified "2023-10-16" @default.
- W3136298903 title "Combined in silico and in vitro approaches identified the antipsychotic drug lurasidone and the antiviral drug elbasvir as SARS-CoV2 and HCoV-OC43 inhibitors" @default.
- W3136298903 cites W10914455 @default.
- W3136298903 cites W1526205344 @default.
- W3136298903 cites W1981743826 @default.
- W3136298903 cites W1988135057 @default.
- W3136298903 cites W2008736019 @default.
- W3136298903 cites W2013669585 @default.
- W3136298903 cites W2015161294 @default.
- W3136298903 cites W2020347526 @default.
- W3136298903 cites W2042643208 @default.
- W3136298903 cites W2044936103 @default.
- W3136298903 cites W2065496099 @default.
- W3136298903 cites W2080653934 @default.
- W3136298903 cites W2081912151 @default.
- W3136298903 cites W2104474203 @default.
- W3136298903 cites W2105668062 @default.
- W3136298903 cites W2107029002 @default.
- W3136298903 cites W2134967712 @default.
- W3136298903 cites W2142291585 @default.
- W3136298903 cites W2169678694 @default.
- W3136298903 cites W2306794997 @default.
- W3136298903 cites W2516533647 @default.
- W3136298903 cites W2528927644 @default.
- W3136298903 cites W2609300759 @default.
- W3136298903 cites W2791115930 @default.
- W3136298903 cites W2808077517 @default.
- W3136298903 cites W2914796231 @default.
- W3136298903 cites W2918873120 @default.
- W3136298903 cites W2999629617 @default.
- W3136298903 cites W3004318991 @default.
- W3136298903 cites W3005212621 @default.
- W3136298903 cites W3006962945 @default.
- W3136298903 cites W3010673910 @default.
- W3136298903 cites W3012767430 @default.
- W3136298903 cites W3013230435 @default.
- W3136298903 cites W3015429854 @default.
- W3136298903 cites W3015608194 @default.
- W3136298903 cites W3016525638 @default.
- W3136298903 cites W3022285953 @default.
- W3136298903 cites W3024856896 @default.
- W3136298903 cites W3027236388 @default.
- W3136298903 cites W3033960862 @default.
- W3136298903 cites W3035854673 @default.
- W3136298903 cites W3036391214 @default.
- W3136298903 cites W3043831045 @default.
- W3136298903 cites W3048213904 @default.
- W3136298903 cites W3050026397 @default.
- W3136298903 cites W3085008014 @default.
- W3136298903 cites W3089874494 @default.
- W3136298903 cites W3094021184 @default.
- W3136298903 cites W3147425578 @default.
- W3136298903 cites W3151357660 @default.
- W3136298903 cites W3152632743 @default.
- W3136298903 cites W3157939513 @default.
- W3136298903 cites W4255148681 @default.
- W3136298903 cites W4308148743 @default.
- W3136298903 cites W779713062 @default.
- W3136298903 doi "https://doi.org/10.1016/j.antiviral.2021.105055" @default.
- W3136298903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7944860" @default.
- W3136298903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33713730" @default.
- W3136298903 hasPublicationYear "2021" @default.
- W3136298903 type Work @default.
- W3136298903 sameAs 3136298903 @default.
- W3136298903 citedByCount "22" @default.
- W3136298903 countsByYear W31362989032021 @default.
- W3136298903 countsByYear W31362989032022 @default.
- W3136298903 countsByYear W31362989032023 @default.
- W3136298903 crossrefType "journal-article" @default.
- W3136298903 hasAuthorship W3136298903A5013706096 @default.
- W3136298903 hasAuthorship W3136298903A5020364767 @default.
- W3136298903 hasAuthorship W3136298903A5026529883 @default.
- W3136298903 hasAuthorship W3136298903A5034485871 @default.
- W3136298903 hasAuthorship W3136298903A5034854833 @default.
- W3136298903 hasAuthorship W3136298903A5055712810 @default.
- W3136298903 hasAuthorship W3136298903A5056221917 @default.
- W3136298903 hasAuthorship W3136298903A5057063089 @default.
- W3136298903 hasAuthorship W3136298903A5066081837 @default.
- W3136298903 hasBestOaLocation W31362989031 @default.
- W3136298903 hasConcept C104317684 @default.
- W3136298903 hasConcept C118552586 @default.
- W3136298903 hasConcept C142724271 @default.
- W3136298903 hasConcept C159047783 @default.
- W3136298903 hasConcept C2522874641 @default.
- W3136298903 hasConcept C2775905019 @default.
- W3136298903 hasConcept C2776412080 @default.