FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136299281> ?p ?o ?g. }

• W3136299281 endingPage "74" @default.
• W3136299281 startingPage "74" @default.
• W3136299281 abstract "The optimization of process parameters in the pharmaceutical industry is often carried out according to the Quality by Design (QbD) concept. QbD also emphasizes that continuous improvement should be performed in life cycle management. Process parameters that are difficult to control in actual production can be regarded as noise parameters. In this study, based on the QbD concept, the ethanol precipitation process of Carthami Flos extract was optimized, considering a noise parameter. The density of the concentrated extract, ethanol concentration, the volume ratio of ethanol to concentrated extract, stirring time after ethanol addition, and refrigeration temperature were selected as critical process parameters (CPPs), using a definitive screening design. The mathematical models among CPPs and evaluation indicators were established. Considering that the refrigeration temperature of industrial ethanol precipitation is often difficult to control with seasonal changes, refrigeration temperature was treated as a noise parameter. A calculation method for the design space in the presence of the noise parameter was proposed. The design space was calculated according to the probability of reaching the standards of evaluation indicators. Controlling parameters within the design space was expected to reduce the influence of noise parameter fluctuations on the quality of the ethanol precipitation supernatant. With more data obtained, the design space was updated. In industry, it is also recommended to adopt a similar idea: that is, continuing to collect industrial data and regularly updating mathematical models, which can further update the design space and make it more stable and reliable." @default.
• W3136299281 created "2021-03-29" @default.
• W3136299281 creator A5045409953 @default.
• W3136299281 creator A5080652074 @default.
• W3136299281 creator A5089277775 @default.
• W3136299281 date "2021-05-24" @default.
• W3136299281 modified "2023-10-16" @default.
• W3136299281 title "Design Space Calculation and Continuous Improvement Considering a Noise Parameter: A Case Study of Ethanol Precipitation Process Optimization for Carthami Flos Extract" @default.
• W3136299281 cites W1573057140 @default.
• W3136299281 cites W1985835056 @default.
• W3136299281 cites W2007858371 @default.
• W3136299281 cites W2035313565 @default.
• W3136299281 cites W2039473536 @default.
• W3136299281 cites W2064184982 @default.
• W3136299281 cites W2083188987 @default.
• W3136299281 cites W2520221904 @default.
• W3136299281 cites W2531461991 @default.
• W3136299281 cites W2612697045 @default.
• W3136299281 cites W2805852937 @default.
• W3136299281 cites W2841997317 @default.
• W3136299281 cites W2884756440 @default.
• W3136299281 cites W2885596411 @default.
• W3136299281 cites W2899199611 @default.
• W3136299281 cites W2975500420 @default.
• W3136299281 cites W2976544874 @default.
• W3136299281 cites W2979783930 @default.
• W3136299281 cites W2986261626 @default.
• W3136299281 cites W2988017220 @default.
• W3136299281 cites W2988145975 @default.
• W3136299281 cites W2994621310 @default.
• W3136299281 cites W3042862687 @default.
• W3136299281 cites W3043804529 @default.
• W3136299281 cites W3045965678 @default.
• W3136299281 cites W3047872402 @default.
• W3136299281 cites W3090585812 @default.
• W3136299281 cites W3094706777 @default.
• W3136299281 doi "https://doi.org/10.3390/separations8060074" @default.
• W3136299281 hasPublicationYear "2021" @default.
• W3136299281 type Work @default.
• W3136299281 sameAs 3136299281 @default.
• W3136299281 citedByCount "5" @default.
• W3136299281 countsByYear W31362992812021 @default.
• W3136299281 countsByYear W31362992812022 @default.
• W3136299281 countsByYear W31362992812023 @default.
• W3136299281 crossrefType "journal-article" @default.
• W3136299281 hasAuthorship W3136299281A5045409953 @default.
• W3136299281 hasAuthorship W3136299281A5080652074 @default.
• W3136299281 hasAuthorship W3136299281A5089277775 @default.
• W3136299281 hasBestOaLocation W31362992811 @default.
• W3136299281 hasConcept C115961682 @default.
• W3136299281 hasConcept C127413603 @default.
• W3136299281 hasConcept C154945302 @default.
• W3136299281 hasConcept C185592680 @default.
• W3136299281 hasConcept C204320433 @default.
• W3136299281 hasConcept C21547014 @default.
• W3136299281 hasConcept C21880701 @default.
• W3136299281 hasConcept C2775924081 @default.
• W3136299281 hasConcept C2775963812 @default.
• W3136299281 hasConcept C2776207758 @default.
• W3136299281 hasConcept C2778004101 @default.
• W3136299281 hasConcept C2778711105 @default.
• W3136299281 hasConcept C33923547 @default.
• W3136299281 hasConcept C41008148 @default.
• W3136299281 hasConcept C47446073 @default.
• W3136299281 hasConcept C55493867 @default.
• W3136299281 hasConcept C69907114 @default.
• W3136299281 hasConcept C78519656 @default.
• W3136299281 hasConcept C99498987 @default.
• W3136299281 hasConceptScore W3136299281C115961682 @default.
• W3136299281 hasConceptScore W3136299281C127413603 @default.
• W3136299281 hasConceptScore W3136299281C154945302 @default.
• W3136299281 hasConceptScore W3136299281C185592680 @default.
• W3136299281 hasConceptScore W3136299281C204320433 @default.
• W3136299281 hasConceptScore W3136299281C21547014 @default.
• W3136299281 hasConceptScore W3136299281C21880701 @default.
• W3136299281 hasConceptScore W3136299281C2775924081 @default.
• W3136299281 hasConceptScore W3136299281C2775963812 @default.
• W3136299281 hasConceptScore W3136299281C2776207758 @default.
• W3136299281 hasConceptScore W3136299281C2778004101 @default.
• W3136299281 hasConceptScore W3136299281C2778711105 @default.
• W3136299281 hasConceptScore W3136299281C33923547 @default.
• W3136299281 hasConceptScore W3136299281C41008148 @default.
• W3136299281 hasConceptScore W3136299281C47446073 @default.
• W3136299281 hasConceptScore W3136299281C55493867 @default.
• W3136299281 hasConceptScore W3136299281C69907114 @default.
• W3136299281 hasConceptScore W3136299281C78519656 @default.
• W3136299281 hasConceptScore W3136299281C99498987 @default.
• W3136299281 hasIssue "6" @default.
• W3136299281 hasLocation W31362992811 @default.
• W3136299281 hasLocation W31362992812 @default.
• W3136299281 hasOpenAccess W3136299281 @default.
• W3136299281 hasPrimaryLocation W31362992811 @default.
• W3136299281 hasRelatedWork W1125456831 @default.
• W3136299281 hasRelatedWork W1161430262 @default.
• W3136299281 hasRelatedWork W2052075446 @default.
• W3136299281 hasRelatedWork W2073750282 @default.
• W3136299281 hasRelatedWork W2132650451 @default.
• W3136299281 hasRelatedWork W2181493544 @default.

• next