FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136304826> ?p ?o ?g. }

• W3136304826 abstract "Salivary proteins facilitate food perception and digestion, maintain the integrity of the mineralized tooth and oral epithelial surfaces, and shield the oro-digestive tract from environmental hazards and invading pathogens. Saliva, as one of the easiest to collect body fluids, also serves in diagnostic applications, with its proteins providing a window to body health. However, despite the availability of the human saliva proteome, the origins of individual proteins remain unclear. To bridge this gap, we analyzed the transcriptomes of 27 tissue samples derived from the three major types of human adult and fetal salivary glands and integrated these data with the saliva proteome and the proteomes and transcriptomes of 28+ other human organs, with tissue expression confirmed by 3D microscopy. Using these tools, we have linked saliva proteins to their source for the first time, an outcome with significant implications for basic research and diagnostic applications. Furthermore, our study represents the first comparative transcriptomic analysis of human adult and fetal exocrine organs, providing evidence that functional specialization occurs late in salivary gland development, and is driven mainly by the transcription of genes encoding secreted saliva proteins. Moreover, we found that dosage of abundant saliva proteins secreted by the salivary glands is primarily regulated at the transcriptional level, and that secreted proteins can be synthesized by distinct subsets of serous acinar cells, revealing hitherto unrecognized heterogeneity in the acinar cell lineage. Our results reveal the functional underpinnings of these secretory organs, paving the way for future investigations into saliva biology and pathology." @default.
• W3136304826 created "2021-03-29" @default.
• W3136304826 creator A5034267283 @default.
• W3136304826 creator A5040408148 @default.
• W3136304826 creator A5049621619 @default.
• W3136304826 creator A5057912428 @default.
• W3136304826 creator A5060466494 @default.
• W3136304826 creator A5064454790 @default.
• W3136304826 creator A5067374817 @default.
• W3136304826 creator A5067678614 @default.
• W3136304826 creator A5068194077 @default.
• W3136304826 creator A5075090706 @default.
• W3136304826 creator A5089236762 @default.
• W3136304826 date "2020-01-01" @default.
• W3136304826 modified "2023-09-23" @default.
• W3136304826 title "Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva" @default.
• W3136304826 doi "https://doi.org/10.2139/ssrn.3565016" @default.
• W3136304826 hasPublicationYear "2020" @default.
• W3136304826 type Work @default.
• W3136304826 sameAs 3136304826 @default.
• W3136304826 citedByCount "0" @default.
• W3136304826 crossrefType "journal-article" @default.
• W3136304826 hasAuthorship W3136304826A5034267283 @default.
• W3136304826 hasAuthorship W3136304826A5040408148 @default.
• W3136304826 hasAuthorship W3136304826A5049621619 @default.
• W3136304826 hasAuthorship W3136304826A5057912428 @default.
• W3136304826 hasAuthorship W3136304826A5060466494 @default.
• W3136304826 hasAuthorship W3136304826A5064454790 @default.
• W3136304826 hasAuthorship W3136304826A5067374817 @default.
• W3136304826 hasAuthorship W3136304826A5067678614 @default.
• W3136304826 hasAuthorship W3136304826A5068194077 @default.
• W3136304826 hasAuthorship W3136304826A5075090706 @default.
• W3136304826 hasAuthorship W3136304826A5089236762 @default.
• W3136304826 hasBestOaLocation W31363048262 @default.
• W3136304826 hasConcept C15744967 @default.
• W3136304826 hasConcept C169760540 @default.
• W3136304826 hasConcept C2778937882 @default.
• W3136304826 hasConcept C2910250545 @default.
• W3136304826 hasConcept C504460877 @default.
• W3136304826 hasConcept C55493867 @default.
• W3136304826 hasConcept C86803240 @default.
• W3136304826 hasConceptScore W3136304826C15744967 @default.
• W3136304826 hasConceptScore W3136304826C169760540 @default.
• W3136304826 hasConceptScore W3136304826C2778937882 @default.
• W3136304826 hasConceptScore W3136304826C2910250545 @default.
• W3136304826 hasConceptScore W3136304826C504460877 @default.
• W3136304826 hasConceptScore W3136304826C55493867 @default.
• W3136304826 hasConceptScore W3136304826C86803240 @default.
• W3136304826 hasLocation W31363048261 @default.
• W3136304826 hasLocation W31363048262 @default.
• W3136304826 hasLocation W31363048263 @default.
• W3136304826 hasOpenAccess W3136304826 @default.
• W3136304826 hasPrimaryLocation W31363048261 @default.
• W3136304826 hasRelatedWork W1551205074 @default.
• W3136304826 hasRelatedWork W1977128154 @default.
• W3136304826 hasRelatedWork W1995273299 @default.
• W3136304826 hasRelatedWork W2004823003 @default.
• W3136304826 hasRelatedWork W2034192725 @default.
• W3136304826 hasRelatedWork W2092919273 @default.
• W3136304826 hasRelatedWork W2140042462 @default.
• W3136304826 hasRelatedWork W22335531 @default.
• W3136304826 hasRelatedWork W2794307983 @default.
• W3136304826 hasRelatedWork W2972137003 @default.
• W3136304826 isParatext "false" @default.
• W3136304826 isRetracted "false" @default.
• W3136304826 magId "3136304826" @default.
• W3136304826 workType "article" @default.