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- W3136305087 abstract "我们开发了一种系统的分析方法,称为棱镜(哺乳动物蛋白质组学调查策略),允许常规,大规模的哺乳动物细胞和组织的大规模蛋白表达谱。棱镜结合了亚细胞分馏,多维液相色谱 - 串联质谱蛋白霰弹枪测序,以及两个新开发的计算机算法,国家数据算法,Satecquest和Goclust,作为快速识别,注释和分类成千上万表达哺乳动物蛋白的手段。棱镜在成人小鼠肺和肝脏中的应用导致超过2,100种独特的蛋白质的高置信度鉴定,包括100多种整体膜蛋白,400个核蛋白和500种无声蛋白质,最大的蛋白质组研究迄今为止进行了这一重要模型生物。将所鉴定的蛋白质自动聚类为基因本体注释组允许简化的大数据集分析,揭示有趣和生理相关的组织和细胞器特异性模式。因此,棱镜为复合哺乳动物蛋白质组进行了有效的深入调查。" @default.
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- W3136305087 date "2003-02-01" @default.
- W3136305087 modified "2023-09-25" @default.
- W3136305087 title "棱镜,哺乳动物的通用大规模蛋白质组学调查策略* s" @default.
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