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• W3136305702 abstract "Purpose : The high content of gadolinium contrast agent used in contrast enhanced MR angiography is very good at shortening T1 effect and high of the signal intensity. In comparison to the low content of gadolinium contrast agent(500mmol), however, 148% high viscosity and 19% high osmolarity raises probability of the occurrence of various side effects when applying to the human body. This study tried to find a way to minimizing the viscosity and osmotic pressure and maximizing the signal intensity to improve the image quality and minimize the probability of the side effect by the dilution of the contrast agent using the characteristic of the high content of gadolinium contrast agent. Materials and Methods : The contrast agent molarity changes by the dilution of the contrast agent and blood the contrast agent is injected and it leads to the signal intensity change. Based on this principle, we made own phantom and do experiment to characterize the signal intensity according to the molarity change. After phantom experiment, we do clinical experiment with the result of the phantom experiment. Clinical experiments was done with 60 patients and we measured the signal intensity in the brain vessels and compared two groups using diluted contrast agent and undiluted contrast agent to know the contrast difference. We used 3.0T MRI and 16channel SENSE NV coil for image acquisition. Results : The signal intensity of the phantom according to the molarity of the contrast agent increased sharply from 0.0125mmol, reached the peak at 20mmol, gradually decreased and then it’s in equilibrium from 200mmol. It means we can get the images that show high signal intensity when the concentration approaches 20mmol by the change of the signal intensity with the dilution of the contrast agent and blood after injecting 1000mmol undiluted contrast agent to the blood vessel. On the basis of the study results, we compared the signal intensity of the blood vessels in the brain through the clinical experiment. The result was all the brain vessels in the imaging range with diluting the high content of the gadolinium contrast agent showed high signal intensity. This result supports the phantom experiment and means it’s better using the 500mmol diluted contrast agent than using 1000mmol undiluted contrast agent because it’s easier to approach 20mmol that makes the highest signal intensity and gets the high signal intensity image. Conclusion : This study has the limitations that it couldn’t measure the viscosity and the osmotic pressure quantative. Nevertheless, this study has a significance that it come up with minimizing the high viscosity and osmotic pressure which can cause side effects and improving the image quality by the method of dilution with analyzing the characteristics of the high content of gadolinium contrast agent." @default.
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• W3136305702 date "2014-12-31" @default.
• W3136305702 modified "2023-09-23" @default.
• W3136305702 title "조영제 mol농도 변화의 신호강도 분석을 통한 조영증강 자기공명혈관조영검사의 질 향상에 관한 연구" @default.
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