FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136308597> ?p ?o ?g. }

• W3136308597 abstract "ABSTRACT Astroglial excitatory amino acid transporter 2 (EAAT2, GLT-1, SLC1A2) regulates the duration and extent of neuronal excitation by removing glutamate from the synaptic cleft. Human patients with altered EAAT2 function exhibit epileptic seizures, suggesting an important role for astroglial glutamate transporters in balancing neuronal excitability. To study the impact of EAAT2 function at the neural network levels, we generated eaat2a mutant zebrafish. We observed that eaat2a-/- mutant zebrafish larvae display recurrent spontaneous and light-induced seizures in neurons and astroglia, which coincide with an abrupt increase in extracellular glutamate levels. In stark contrast to this hyperexcitability, basal brain activity was surprisingly reduced in eaat2a-/- mutant animals, which manifested in decreased locomotion, neuronal and astroglial calcium signals. Our results reveal an unexpected key role of the astroglial EAAT2a in balancing brain excitability, affecting both neuronal and astroglial network activity." @default.
• W3136308597 created "2021-03-29" @default.
• W3136308597 creator A5005569504 @default.
• W3136308597 creator A5016536397 @default.
• W3136308597 creator A5028397897 @default.
• W3136308597 creator A5039393173 @default.
• W3136308597 creator A5043629469 @default.
• W3136308597 creator A5050105328 @default.
• W3136308597 creator A5062506501 @default.
• W3136308597 creator A5068990542 @default.
• W3136308597 creator A5069309989 @default.
• W3136308597 creator A5091171261 @default.
• W3136308597 date "2021-03-17" @default.
• W3136308597 modified "2023-09-27" @default.
• W3136308597 title "Loss of the glial glutamate transporter eaat2a leads to a combined developmental and epileptic encephalopathy in zebrafish" @default.
• W3136308597 cites W14177003 @default.
• W3136308597 cites W1498909962 @default.
• W3136308597 cites W1749057191 @default.
• W3136308597 cites W1907352358 @default.
• W3136308597 cites W1942144965 @default.
• W3136308597 cites W1975004590 @default.
• W3136308597 cites W1977059167 @default.
• W3136308597 cites W1978437325 @default.
• W3136308597 cites W1981307673 @default.
• W3136308597 cites W1983100194 @default.
• W3136308597 cites W1992521533 @default.
• W3136308597 cites W1994675927 @default.
• W3136308597 cites W1999603779 @default.
• W3136308597 cites W2012777073 @default.
• W3136308597 cites W2014611177 @default.
• W3136308597 cites W2018425216 @default.
• W3136308597 cites W2031034568 @default.
• W3136308597 cites W2040275236 @default.
• W3136308597 cites W2048089240 @default.
• W3136308597 cites W2048610961 @default.
• W3136308597 cites W2048916015 @default.
• W3136308597 cites W2051685988 @default.
• W3136308597 cites W2057759106 @default.
• W3136308597 cites W2063261415 @default.
• W3136308597 cites W2064328134 @default.
• W3136308597 cites W2068687319 @default.
• W3136308597 cites W2069498125 @default.
• W3136308597 cites W2080092859 @default.
• W3136308597 cites W2080320300 @default.
• W3136308597 cites W2083695557 @default.
• W3136308597 cites W2084771878 @default.
• W3136308597 cites W2097156979 @default.
• W3136308597 cites W2100494200 @default.
• W3136308597 cites W2105832751 @default.
• W3136308597 cites W2109576877 @default.
• W3136308597 cites W2117451307 @default.
• W3136308597 cites W2117940227 @default.
• W3136308597 cites W2128744963 @default.
• W3136308597 cites W2133872729 @default.
• W3136308597 cites W2138734189 @default.
• W3136308597 cites W2143337761 @default.
• W3136308597 cites W2149498611 @default.
• W3136308597 cites W2153232075 @default.
• W3136308597 cites W2159255304 @default.
• W3136308597 cites W2160644313 @default.
• W3136308597 cites W2164695230 @default.
• W3136308597 cites W2166165431 @default.
• W3136308597 cites W2179464849 @default.
• W3136308597 cites W2260140125 @default.
• W3136308597 cites W238111488 @default.
• W3136308597 cites W2486138415 @default.
• W3136308597 cites W2488891822 @default.
• W3136308597 cites W2561670917 @default.
• W3136308597 cites W2565139347 @default.
• W3136308597 cites W2592509339 @default.
• W3136308597 cites W2594644573 @default.
• W3136308597 cites W2620828900 @default.
• W3136308597 cites W2622139009 @default.
• W3136308597 cites W2622256805 @default.
• W3136308597 cites W2725788277 @default.
• W3136308597 cites W2745067258 @default.
• W3136308597 cites W2755498014 @default.
• W3136308597 cites W2765155499 @default.
• W3136308597 cites W2765406496 @default.
• W3136308597 cites W2784251784 @default.
• W3136308597 cites W2789385023 @default.
• W3136308597 cites W2790393975 @default.
• W3136308597 cites W2883241721 @default.
• W3136308597 cites W2896293784 @default.
• W3136308597 cites W2908047046 @default.
• W3136308597 cites W2911011469 @default.
• W3136308597 cites W2911282232 @default.
• W3136308597 cites W2916711365 @default.
• W3136308597 cites W2921207256 @default.
• W3136308597 cites W2933696521 @default.
• W3136308597 cites W2950418175 @default.
• W3136308597 cites W2951411842 @default.
• W3136308597 cites W2952326088 @default.
• W3136308597 cites W2969719419 @default.
• W3136308597 cites W2978959544 @default.
• W3136308597 cites W2995634650 @default.
• W3136308597 cites W2997366554 @default.
• W3136308597 cites W3001520899 @default.
• W3136308597 cites W3008080069 @default.
• W3136308597 cites W3008738360 @default.

• next