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- W3136321386 abstract "Background: High blood pressure is frequently associated with metabolic alterations such as insulin resistance, impaired glucose tolerance, dyslipidaemia and obesity. Moxonidine, a selective imidazoline receptor agonist, reduces activity of sympathetic nervous system and lowers blood pressure, and has been shown to have benecial effects on lipid and carbohydrate metabolism. The present study has been conducted to evaluate antihypertensive efcacy of moxonidine and compare it with amlodipine in mild to moderate hypertension in obese patients. Methods: This was an open-label randomized study. Patients were divided into two groups of 50 patients each, rst group was given amlodipine 5 mg daily and the second group was given moxonidine 0.2 mg once daily. At the end of 8 weeks, the therapeutic effects of both regimes on blood pressure in obese patients with stage 1 and stage 2 hypertension were compared and also with lipid prole, fasting sugars and microalbuminuria. Results: The study involved 100 participants with a mean age of 51.12±6.25 years and 48.88±5.15 years in moxonidine group and amlodipine group, respectively. Systolic and diastolic blood pressure reduction was signicant in both groups at 8-weeks (p<0.001). The reduction in FBS (p=0.008), total cholesterol (p=0.04), serum triglycerides (p<0.001) and increase in HDL (p=0.02) were all signicant in moxonidine group, but LDL reduction was not signicant. In amlodipine group, change in FBS, total cholesterol, serum triglycerides, HDL and LDL levels were all insignicant. There was also signicant reduction in microalbuminuria in moxonidine group. Conclusion: Moxonidine and amlodipine are equally effective antihypertensives and safe in obese hypertensives. Moxondine has additional favourable effects on lipid prole (serum cholesterol, TGs and LDL), fasting blood glucose and microalbuminuria." @default.
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- W3136321386 date "2021-02-01" @default.
- W3136321386 modified "2023-09-27" @default.
- W3136321386 title "COMPARATIVE EVALUATION OF THERAPEUTIC EFFECT OF MOXONIDINE VERSUS AMLODIPINE ON BLOOD PRESSURE IN OBESE HYPERTENSIVES" @default.
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- W3136321386 doi "https://doi.org/10.36106/ijsr/6226887" @default.
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