FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136332016> ?p ?o ?g. }

• W3136332016 endingPage "S235" @default.
• W3136332016 startingPage "S234" @default.
• W3136332016 abstract "PurposeTo investigate the impact of cerebral reperfusion on cardiac contractile function after normothermic regional perfusion (NRP) after anoxic circulatory death in a porcine model.MethodsThe animals were anaesthetized and biventricular pressure-volume catheters and a pulmonary artery catheter were inserted percutaneously. Through a midline sternotomy, the heparinised animals were cannulated for extracorporeal circulation. Baseline data were obtained before cessation of mechanical ventilation. Death was determined 5 minutes after mechanical asystole and after additional 3 minutes of warm ischemia NRP was started using a heart-lung machine. The animals were randomized before reperfusion to either clamping (CL) (n=8) or non-clamping (NCL) (n=8) of the aortic arch vessels; the infrarenal aorta was clamped in both groups. The NRP-protocol includes early volume loading of the right ventricle, infusion of dobutamine and norepinephrine and gradual wean over 30 minutes. The animals were observed for 180 minutes after weaning from NRP.ResultsAll animals were successfully weaned from NRP. Both groups demonstrated an acceptable cardiac function after weaning with a mean arterial blood pressure above 75 mmHg and low filling pressures. The NCL group received significantly more norepinephrine (p=0.0484) than the CL group. The left ventricle End-systolic pressure-volume relationship as an index of contractility showed improvement in both groups after wean from NRP compared to baseline (p=0.0009). In the CL group, LV contractility showed a tendency to a better improvement compared to the NCL group (p=0.226) (Fig. 1). The RV showed preserved contractility in both groups.ConclusionLV contractility but not RV contractility improves after circulatory death and weaning from NRP. The improvement of the left ventricular contractility tends to be better when the aortic arch vessels are clamped compared to upper-body perfusion. To investigate the impact of cerebral reperfusion on cardiac contractile function after normothermic regional perfusion (NRP) after anoxic circulatory death in a porcine model. The animals were anaesthetized and biventricular pressure-volume catheters and a pulmonary artery catheter were inserted percutaneously. Through a midline sternotomy, the heparinised animals were cannulated for extracorporeal circulation. Baseline data were obtained before cessation of mechanical ventilation. Death was determined 5 minutes after mechanical asystole and after additional 3 minutes of warm ischemia NRP was started using a heart-lung machine. The animals were randomized before reperfusion to either clamping (CL) (n=8) or non-clamping (NCL) (n=8) of the aortic arch vessels; the infrarenal aorta was clamped in both groups. The NRP-protocol includes early volume loading of the right ventricle, infusion of dobutamine and norepinephrine and gradual wean over 30 minutes. The animals were observed for 180 minutes after weaning from NRP. All animals were successfully weaned from NRP. Both groups demonstrated an acceptable cardiac function after weaning with a mean arterial blood pressure above 75 mmHg and low filling pressures. The NCL group received significantly more norepinephrine (p=0.0484) than the CL group. The left ventricle End-systolic pressure-volume relationship as an index of contractility showed improvement in both groups after wean from NRP compared to baseline (p=0.0009). In the CL group, LV contractility showed a tendency to a better improvement compared to the NCL group (p=0.226) (Fig. 1). The RV showed preserved contractility in both groups. LV contractility but not RV contractility improves after circulatory death and weaning from NRP. The improvement of the left ventricular contractility tends to be better when the aortic arch vessels are clamped compared to upper-body perfusion." @default.
• W3136332016 created "2021-03-29" @default.
• W3136332016 creator A5006122120 @default.
• W3136332016 creator A5021756031 @default.
• W3136332016 creator A5030563053 @default.
• W3136332016 creator A5031793547 @default.
• W3136332016 creator A5032430523 @default.
• W3136332016 creator A5033329945 @default.
• W3136332016 creator A5066352277 @default.
• W3136332016 creator A5070421103 @default.
• W3136332016 creator A5076491416 @default.
• W3136332016 date "2021-04-01" @default.
• W3136332016 modified "2023-09-27" @default.
• W3136332016 title "Improvement of Left but Not Right Ventricular Contractility after Circulatory Death and Normothermic Regional Perfusion in a Porcine Model" @default.
• W3136332016 doi "https://doi.org/10.1016/j.healun.2021.01.674" @default.
• W3136332016 hasPublicationYear "2021" @default.
• W3136332016 type Work @default.
• W3136332016 sameAs 3136332016 @default.
• W3136332016 citedByCount "0" @default.
• W3136332016 crossrefType "journal-article" @default.
• W3136332016 hasAuthorship W3136332016A5006122120 @default.
• W3136332016 hasAuthorship W3136332016A5021756031 @default.
• W3136332016 hasAuthorship W3136332016A5030563053 @default.
• W3136332016 hasAuthorship W3136332016A5031793547 @default.
• W3136332016 hasAuthorship W3136332016A5032430523 @default.
• W3136332016 hasAuthorship W3136332016A5033329945 @default.
• W3136332016 hasAuthorship W3136332016A5066352277 @default.
• W3136332016 hasAuthorship W3136332016A5070421103 @default.
• W3136332016 hasAuthorship W3136332016A5076491416 @default.
• W3136332016 hasBestOaLocation W31363320161 @default.
• W3136332016 hasConcept C126322002 @default.
• W3136332016 hasConcept C146957229 @default.
• W3136332016 hasConcept C164705383 @default.
• W3136332016 hasConcept C178853913 @default.
• W3136332016 hasConcept C2778921608 @default.
• W3136332016 hasConcept C2779980429 @default.
• W3136332016 hasConcept C2780940725 @default.
• W3136332016 hasConcept C2781185063 @default.
• W3136332016 hasConcept C2994232697 @default.
• W3136332016 hasConcept C39133596 @default.
• W3136332016 hasConcept C42219234 @default.
• W3136332016 hasConcept C71924100 @default.
• W3136332016 hasConcept C72859922 @default.
• W3136332016 hasConceptScore W3136332016C126322002 @default.
• W3136332016 hasConceptScore W3136332016C146957229 @default.
• W3136332016 hasConceptScore W3136332016C164705383 @default.
• W3136332016 hasConceptScore W3136332016C178853913 @default.
• W3136332016 hasConceptScore W3136332016C2778921608 @default.
• W3136332016 hasConceptScore W3136332016C2779980429 @default.
• W3136332016 hasConceptScore W3136332016C2780940725 @default.
• W3136332016 hasConceptScore W3136332016C2781185063 @default.
• W3136332016 hasConceptScore W3136332016C2994232697 @default.
• W3136332016 hasConceptScore W3136332016C39133596 @default.
• W3136332016 hasConceptScore W3136332016C42219234 @default.
• W3136332016 hasConceptScore W3136332016C71924100 @default.
• W3136332016 hasConceptScore W3136332016C72859922 @default.
• W3136332016 hasIssue "4" @default.
• W3136332016 hasLocation W31363320161 @default.
• W3136332016 hasOpenAccess W3136332016 @default.
• W3136332016 hasPrimaryLocation W31363320161 @default.
• W3136332016 hasRelatedWork W1963940466 @default.
• W3136332016 hasRelatedWork W2031729528 @default.
• W3136332016 hasRelatedWork W2076273099 @default.
• W3136332016 hasRelatedWork W2094475495 @default.
• W3136332016 hasRelatedWork W2402713426 @default.
• W3136332016 hasRelatedWork W2410657007 @default.
• W3136332016 hasRelatedWork W2412704911 @default.
• W3136332016 hasRelatedWork W2431702810 @default.
• W3136332016 hasRelatedWork W2436547916 @default.
• W3136332016 hasRelatedWork W2617407759 @default.
• W3136332016 hasVolume "40" @default.
• W3136332016 isParatext "false" @default.
• W3136332016 isRetracted "false" @default.
• W3136332016 magId "3136332016" @default.
• W3136332016 workType "article" @default.