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- W3136335956 abstract "Abstract Co-transcriptional splicing coordinates the processes of transcription and splicing and is driven by transcription factors (TFs) and diverse RNA-binding proteins (RBPs). Yet the mechanisms by which specific TFs and RBPs function together in context-specific ways to drive precise co-transcriptional splicing at each of thousands of genomic loci remains unknown. Therefore, we have used sex-specific splicing in Drosophila as a model to understand how the function of TFs and RBPs is coordinated to transcribe and process specific RNA transcripts at the correct genomic locations. We show widespread sex-specific transcript diversity occurs much earlier than previously thought and present a new pipeline called time2splice to quantify splicing changes over time. We define several mechanisms by which the essential and functionally-conserved CLAMP TF functions with specific RBPs to precisely regulate co-transcriptional splicing: 1) CLAMP links the DNA of gene bodies of sex-specifically spliced genes directly to the RNA of target genes and physically interacts with snRNA and protein components of the splicing machinery; 2) In males, CLAMP regulates the distribution of the highly conserved RBP M ale le ss (MLE) (RNA Helicase A) to prevent aberrant sex-specific splicing; 3) In females, CLAMP modulates alternative splicing by directly binding to target DNA and RNA and indirectly through regulating the splicing of sex lethal , the master regulator of sex determination. Overall, we provide new insight into how TFs function specifically with RBPs to drive alternative splicing." @default.
- W3136335956 created "2021-03-29" @default.
- W3136335956 creator A5030678862 @default.
- W3136335956 creator A5040377321 @default.
- W3136335956 creator A5050204535 @default.
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- W3136335956 creator A5058182568 @default.
- W3136335956 creator A5062988734 @default.
- W3136335956 creator A5088633021 @default.
- W3136335956 date "2021-03-19" @default.
- W3136335956 modified "2023-09-23" @default.
- W3136335956 title "Sex-specific transcript diversity is regulated by a maternal transcription factor in early<i>Drosophila</i>embryos" @default.
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