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- W3136337273 abstract "Abstract Feeding is an essential part of animal life that is greatly impacted by the sense of taste. Although the characterization of taste-detection at the periphery has been extensive, higher order taste and feeding circuits are still being elucidated. Here, we use an automated closed-loop optogenetic activation screen to detect novel taste and feeding neurons in Drosophila melanogaster. Out of 122 Janelia FlyLight Project GAL4 lines preselected based on expression pattern, we identify six lines that acutely promote feeding and 35 lines that inhibit it. As proof of principle, we follow up on R70C07-GAL4, which labels neurons that strongly inhibit feeding. Using split-GAL4 lines to isolate subsets of the R70C07-GAL4 population, we find both appetitive and aversive neurons. Furthermore, we show that R70C07-GAL4 labels putative second-order taste interneurons that contact both sweet and bitter sensory neurons. These results serve as a resource for further functional dissection of fly feeding circuits." @default.
- W3136337273 created "2021-03-29" @default.
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- W3136337273 date "2021-03-14" @default.
- W3136337273 modified "2023-09-26" @default.
- W3136337273 title "A closed-loop optogenetic screen for neurons controlling feeding in <i>Drosophila</i>" @default.
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- W3136337273 doi "https://doi.org/10.1093/g3journal/jkab073" @default.
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