Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136342385> ?p ?o ?g. }
- W3136342385 abstract "Abstract Inositol requiring enzyme 1 alpha (IRE1α) is one of three signaling sensors in the unfolding protein response (UPR) that alleviates endoplasmic reticulum (ER) stress in cells and functions to promote cell survival. During conditions of irrevocable stress, proapoptotic gene expression is induced to promote cell death. One of the three signaling stressors, IRE1α is an serine/threonine-protein kinase/endoribonuclease (RNase) that promotes nonconventional splicing of XBP1 mRNA that is translated to spliced XBP1 (XBP1s), an active prosurvival transcription factor. Interestingly, elevated IRE1α and XBP1s are both associated with poor cancer survival and drug resistance. In this study, we used next-generation sequencing analyses to demonstrate that triazoloacridone C-1305, a microtubule stabilizing agent that also has topoisomerase II inhibitory activity, dramatically decreases XBP1s mRNA levels and protein production during ER stress conditions, suggesting that C-1305 does this by decreasing IRE1α’s endonuclease activity." @default.
- W3136342385 created "2021-03-29" @default.
- W3136342385 creator A5022864557 @default.
- W3136342385 creator A5024006453 @default.
- W3136342385 creator A5036813232 @default.
- W3136342385 creator A5039708431 @default.
- W3136342385 creator A5044785923 @default.
- W3136342385 creator A5058615793 @default.
- W3136342385 creator A5075050584 @default.
- W3136342385 date "2021-03-17" @default.
- W3136342385 modified "2023-10-01" @default.
- W3136342385 title "Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitor" @default.
- W3136342385 cites W1559486600 @default.
- W3136342385 cites W1970090817 @default.
- W3136342385 cites W1973400283 @default.
- W3136342385 cites W1974191631 @default.
- W3136342385 cites W1985139784 @default.
- W3136342385 cites W1988328014 @default.
- W3136342385 cites W1988482079 @default.
- W3136342385 cites W2005644246 @default.
- W3136342385 cites W2028046413 @default.
- W3136342385 cites W2054631447 @default.
- W3136342385 cites W2066604609 @default.
- W3136342385 cites W2079791855 @default.
- W3136342385 cites W2079820331 @default.
- W3136342385 cites W2085933321 @default.
- W3136342385 cites W2106314483 @default.
- W3136342385 cites W2107277218 @default.
- W3136342385 cites W2108128188 @default.
- W3136342385 cites W2112286580 @default.
- W3136342385 cites W2112517611 @default.
- W3136342385 cites W2132629607 @default.
- W3136342385 cites W2134526812 @default.
- W3136342385 cites W2137662702 @default.
- W3136342385 cites W2141458291 @default.
- W3136342385 cites W2158837517 @default.
- W3136342385 cites W2177067994 @default.
- W3136342385 cites W2179438025 @default.
- W3136342385 cites W2214858649 @default.
- W3136342385 cites W2345356016 @default.
- W3136342385 cites W2345737547 @default.
- W3136342385 cites W2438049444 @default.
- W3136342385 cites W2763492642 @default.
- W3136342385 cites W2788525877 @default.
- W3136342385 cites W2790238149 @default.
- W3136342385 cites W2885058366 @default.
- W3136342385 cites W2886095503 @default.
- W3136342385 cites W2891435420 @default.
- W3136342385 cites W2897704361 @default.
- W3136342385 cites W2913687928 @default.
- W3136342385 cites W2914443670 @default.
- W3136342385 cites W2951677704 @default.
- W3136342385 cites W2961368723 @default.
- W3136342385 cites W2971237125 @default.
- W3136342385 cites W2990124410 @default.
- W3136342385 cites W2996833414 @default.
- W3136342385 cites W3005001782 @default.
- W3136342385 cites W3012605527 @default.
- W3136342385 cites W3014822181 @default.
- W3136342385 cites W3015681485 @default.
- W3136342385 cites W3017712133 @default.
- W3136342385 cites W3030054993 @default.
- W3136342385 cites W3034609286 @default.
- W3136342385 cites W3080597606 @default.
- W3136342385 cites W3093659999 @default.
- W3136342385 cites W3113149839 @default.
- W3136342385 doi "https://doi.org/10.1186/s11658-021-00255-y" @default.
- W3136342385 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7968329" @default.
- W3136342385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33730996" @default.
- W3136342385 hasPublicationYear "2021" @default.
- W3136342385 type Work @default.
- W3136342385 sameAs 3136342385 @default.
- W3136342385 citedByCount "8" @default.
- W3136342385 countsByYear W31363423852021 @default.
- W3136342385 countsByYear W31363423852022 @default.
- W3136342385 countsByYear W31363423852023 @default.
- W3136342385 crossrefType "journal-article" @default.
- W3136342385 hasAuthorship W3136342385A5022864557 @default.
- W3136342385 hasAuthorship W3136342385A5024006453 @default.
- W3136342385 hasAuthorship W3136342385A5036813232 @default.
- W3136342385 hasAuthorship W3136342385A5039708431 @default.
- W3136342385 hasAuthorship W3136342385A5044785923 @default.
- W3136342385 hasAuthorship W3136342385A5058615793 @default.
- W3136342385 hasAuthorship W3136342385A5075050584 @default.
- W3136342385 hasBestOaLocation W31363423851 @default.
- W3136342385 hasConcept C104317684 @default.
- W3136342385 hasConcept C10879258 @default.
- W3136342385 hasConcept C139447449 @default.
- W3136342385 hasConcept C153911025 @default.
- W3136342385 hasConcept C158617107 @default.
- W3136342385 hasConcept C2780102198 @default.
- W3136342385 hasConcept C2781331208 @default.
- W3136342385 hasConcept C54458228 @default.
- W3136342385 hasConcept C55493867 @default.
- W3136342385 hasConcept C67705224 @default.
- W3136342385 hasConcept C86803240 @default.
- W3136342385 hasConcept C95444343 @default.
- W3136342385 hasConceptScore W3136342385C104317684 @default.
- W3136342385 hasConceptScore W3136342385C10879258 @default.
- W3136342385 hasConceptScore W3136342385C139447449 @default.