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- W3136342579 endingPage "521" @default.
- W3136342579 startingPage "521" @default.
- W3136342579 abstract "Neglected Tropical Diseases (NTDs), particularly those caused by parasites, remain a major Public Health problem in tropical and subtropical regions, with 10% of the world population being infected. Their management and control have been traditionally hampered, among other factors, by the difficulty to deploy rapid, specific, and affordable diagnostic tools in low resource settings. This is especially true for complex PCR-based methods. Isothermal nucleic acid amplification techniques, particularly loop-mediated isothermal amplification (LAMP), appeared in the early 21st century as an alternative to PCR, allowing for a much more affordable molecular diagnostic. Here, we present the status of LAMP assays development in parasite-caused NTDs. We address the progress made in different research applications of the technique: xenomonitoring, epidemiological studies, work in animal models and clinical application both for diagnosis and evaluation of treatment success. Finally, we try to shed a light on the improvements needed to achieve a true point-of-care test and the future perspectives in this field." @default.
- W3136342579 created "2021-03-29" @default.
- W3136342579 creator A5023659030 @default.
- W3136342579 creator A5053924318 @default.
- W3136342579 creator A5056337927 @default.
- W3136342579 date "2021-03-15" @default.
- W3136342579 modified "2023-10-16" @default.
- W3136342579 title "LAMP in Neglected Tropical Diseases: A Focus on Parasites" @default.
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