Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136343760> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3136343760 endingPage "S493" @default.
- W3136343760 startingPage "S493" @default.
- W3136343760 abstract "IntroductionHeart transplant candidates with allosensitization face higher waitlist mortality and may have inferior post-transplant outcomes. We present our experience with a multi-drug desensitization regimen including daratumumab, an anti-CD38 monoclonal antibody, in a 51-year-old female listed for heart transplant.Case ReportThe patient presented with heart failure due to NICMP with LMNA mutation. She was listed for heart transplant with 94% class I PRAs and 98% class II PRAs. Given level of sensitization, the decision was made to desensitize with plasmapheresis (5 sessions), IVIG (2 g/kg), bortezomib (4 doses), and tocilizumab (1 dose). During this treatment she experienced neutropenia requiring bortezomib dose reduction. Following these therapies her class I PRA decreased to 36%, but her class II PRA persisted at 99%. Immunodominant HLA antibodies are trended in Figure 1. She subsequently received additional plasmapheresis (6 sessions) with IVIG (2 g/kg) and rituximab (1 dose). PRAs remained consistent; HLA MFIs remained high (Figure 1). She was then treated with daratumumab weekly. She received 8 doses; the last dose was received the day prior to transplant. Her class I PRA decreased to 13% and class II PRA was 99% at the time of transplant. Her crossmatch was negative, and she received steroid induction alone. Maintenance immunosuppression consisted of tacrolimus, mycophenolate, and prednisone. Her tacrolimus was therapeutic by POD6 with a goal of 10-15 mcg/mL. By month 11 post-transplant she has had no episodes of cellular or antibody-mediated rejection. Graft function has been stable with ejection fraction >60%. All DSA screening has been negative and she has not developed any significant infections post-transplant.SummaryDaratumumab, as part of a desensitization regimen, appears to be safe and effective in sensitized patients awaiting heart transplant and was not associated with post-op complications, and may have contributed to prevention of antibody-mediated rejection post-transplant." @default.
- W3136343760 created "2021-03-29" @default.
- W3136343760 creator A5014510253 @default.
- W3136343760 creator A5015999831 @default.
- W3136343760 creator A5031679402 @default.
- W3136343760 creator A5041027183 @default.
- W3136343760 creator A5055801916 @default.
- W3136343760 creator A5063467006 @default.
- W3136343760 creator A5073340288 @default.
- W3136343760 date "2021-04-01" @default.
- W3136343760 modified "2023-10-06" @default.
- W3136343760 title "Use of Daratumumab for Desensitization Prior to Cardiac Transplantation: A Case Report" @default.
- W3136343760 doi "https://doi.org/10.1016/j.healun.2021.01.2015" @default.
- W3136343760 hasPublicationYear "2021" @default.
- W3136343760 type Work @default.
- W3136343760 sameAs 3136343760 @default.
- W3136343760 citedByCount "4" @default.
- W3136343760 countsByYear W31363437602022 @default.
- W3136343760 countsByYear W31363437602023 @default.
- W3136343760 crossrefType "journal-article" @default.
- W3136343760 hasAuthorship W3136343760A5014510253 @default.
- W3136343760 hasAuthorship W3136343760A5015999831 @default.
- W3136343760 hasAuthorship W3136343760A5031679402 @default.
- W3136343760 hasAuthorship W3136343760A5041027183 @default.
- W3136343760 hasAuthorship W3136343760A5055801916 @default.
- W3136343760 hasAuthorship W3136343760A5063467006 @default.
- W3136343760 hasAuthorship W3136343760A5073340288 @default.
- W3136343760 hasBestOaLocation W31363437601 @default.
- W3136343760 hasConcept C126322002 @default.
- W3136343760 hasConcept C128057223 @default.
- W3136343760 hasConcept C141071460 @default.
- W3136343760 hasConcept C159654299 @default.
- W3136343760 hasConcept C203014093 @default.
- W3136343760 hasConcept C2776364478 @default.
- W3136343760 hasConcept C2777478702 @default.
- W3136343760 hasConcept C2778720950 @default.
- W3136343760 hasConcept C2778842783 @default.
- W3136343760 hasConcept C2778849806 @default.
- W3136343760 hasConcept C2779338263 @default.
- W3136343760 hasConcept C2780252810 @default.
- W3136343760 hasConcept C2780653079 @default.
- W3136343760 hasConcept C2781119759 @default.
- W3136343760 hasConcept C2911091166 @default.
- W3136343760 hasConcept C71924100 @default.
- W3136343760 hasConceptScore W3136343760C126322002 @default.
- W3136343760 hasConceptScore W3136343760C128057223 @default.
- W3136343760 hasConceptScore W3136343760C141071460 @default.
- W3136343760 hasConceptScore W3136343760C159654299 @default.
- W3136343760 hasConceptScore W3136343760C203014093 @default.
- W3136343760 hasConceptScore W3136343760C2776364478 @default.
- W3136343760 hasConceptScore W3136343760C2777478702 @default.
- W3136343760 hasConceptScore W3136343760C2778720950 @default.
- W3136343760 hasConceptScore W3136343760C2778842783 @default.
- W3136343760 hasConceptScore W3136343760C2778849806 @default.
- W3136343760 hasConceptScore W3136343760C2779338263 @default.
- W3136343760 hasConceptScore W3136343760C2780252810 @default.
- W3136343760 hasConceptScore W3136343760C2780653079 @default.
- W3136343760 hasConceptScore W3136343760C2781119759 @default.
- W3136343760 hasConceptScore W3136343760C2911091166 @default.
- W3136343760 hasConceptScore W3136343760C71924100 @default.
- W3136343760 hasIssue "4" @default.
- W3136343760 hasLocation W31363437601 @default.
- W3136343760 hasOpenAccess W3136343760 @default.
- W3136343760 hasPrimaryLocation W31363437601 @default.
- W3136343760 hasRelatedWork W2076316204 @default.
- W3136343760 hasRelatedWork W2106387428 @default.
- W3136343760 hasRelatedWork W2143803333 @default.
- W3136343760 hasRelatedWork W2163052847 @default.
- W3136343760 hasRelatedWork W2171070458 @default.
- W3136343760 hasRelatedWork W2376833857 @default.
- W3136343760 hasRelatedWork W2384341772 @default.
- W3136343760 hasRelatedWork W2508659662 @default.
- W3136343760 hasRelatedWork W2525095138 @default.
- W3136343760 hasRelatedWork W2783888490 @default.
- W3136343760 hasVolume "40" @default.
- W3136343760 isParatext "false" @default.
- W3136343760 isRetracted "false" @default.
- W3136343760 magId "3136343760" @default.
- W3136343760 workType "article" @default.