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- W3136345567 endingPage "1737" @default.
- W3136345567 startingPage "1713" @default.
- W3136345567 abstract "Plasma membrane transporters play pivotal roles in the import of nutrients, including sugars, amino acids, nucleobases, carboxylic acids, and metal ions, that surround fungal cells. The selective removal of these transporters by endocytosis is one of the most important regulatory mechanisms that ensures a rapid adaptation of cells to the changing environment (e.g., nutrient fluctuations or different stresses). At the heart of this mechanism lies a network of proteins that includes the arrestin‐related trafficking adaptors (ARTs) which link the ubiquitin ligase Rsp5 to nutrient transporters and endocytic factors. Transporter conformational changes, as well as dynamic interactions between its cytosolic termini/loops and with lipids of the plasma membrane, are also critical during the endocytic process. Here, we review the current knowledge and recent findings on the molecular mechanisms involved in nutrient transporter endocytosis, both in the budding yeast Saccharomyces cerevisiae and in some species of the filamentous fungus Aspergillus. We elaborate on the physiological importance of tightly regulated endocytosis for cellular fitness under dynamic conditions found in nature and highlight how further understanding and engineering of this process is essential to maximize titer, rate and yield (TRY)-values of engineered cell factories in industrial biotechnological processes." @default.
- W3136345567 created "2021-03-29" @default.
- W3136345567 creator A5016695766 @default.
- W3136345567 creator A5025910449 @default.
- W3136345567 creator A5035568930 @default.
- W3136345567 creator A5055395745 @default.
- W3136345567 creator A5068117758 @default.
- W3136345567 creator A5069488232 @default.
- W3136345567 creator A5085063399 @default.
- W3136345567 date "2021-01-01" @default.
- W3136345567 modified "2023-10-15" @default.
- W3136345567 title "Endocytosis of nutrient transporters in fungi: The ART of connecting signaling and trafficking" @default.
- W3136345567 cites W1482148673 @default.
- W3136345567 cites W1553222558 @default.
- W3136345567 cites W1574725056 @default.
- W3136345567 cites W1582526635 @default.
- W3136345567 cites W1585201495 @default.
- W3136345567 cites W1585347403 @default.
- W3136345567 cites W1602280532 @default.
- W3136345567 cites W1630147022 @default.
- W3136345567 cites W1905826330 @default.
- W3136345567 cites W1914523915 @default.
- W3136345567 cites W1920557983 @default.
- W3136345567 cites W1928922088 @default.
- W3136345567 cites W1942410765 @default.
- W3136345567 cites W1965859532 @default.
- W3136345567 cites W1966324092 @default.
- W3136345567 cites W1966642383 @default.
- W3136345567 cites W1968652158 @default.
- W3136345567 cites W1970230813 @default.
- W3136345567 cites W1971094336 @default.
- W3136345567 cites W1972120846 @default.
- W3136345567 cites W1975302004 @default.
- W3136345567 cites W1975378006 @default.
- W3136345567 cites W1978919717 @default.
- W3136345567 cites W1979096574 @default.
- W3136345567 cites W1980223316 @default.
- W3136345567 cites W1981919911 @default.
- W3136345567 cites W1982606786 @default.
- W3136345567 cites W1982932698 @default.
- W3136345567 cites W1984303321 @default.
- W3136345567 cites W1984632019 @default.
- W3136345567 cites W1984706267 @default.
- W3136345567 cites W1986806423 @default.
- W3136345567 cites W1987108981 @default.
- W3136345567 cites W1987612677 @default.
- W3136345567 cites W1991929397 @default.
- W3136345567 cites W1993028138 @default.
- W3136345567 cites W1993718303 @default.
- W3136345567 cites W1995786397 @default.
- W3136345567 cites W1996119276 @default.
- W3136345567 cites W1997664932 @default.
- W3136345567 cites W1998069931 @default.
- W3136345567 cites W1999359085 @default.
- W3136345567 cites W2000461833 @default.
- W3136345567 cites W2001239365 @default.
- W3136345567 cites W2003609221 @default.
- W3136345567 cites W2004926885 @default.
- W3136345567 cites W2005094475 @default.
- W3136345567 cites W2007945179 @default.
- W3136345567 cites W2008141632 @default.
- W3136345567 cites W2008525422 @default.
- W3136345567 cites W2008832186 @default.
- W3136345567 cites W2009188703 @default.
- W3136345567 cites W2012390982 @default.
- W3136345567 cites W2016960317 @default.
- W3136345567 cites W2017451949 @default.
- W3136345567 cites W2018327145 @default.
- W3136345567 cites W2018807628 @default.
- W3136345567 cites W2019870906 @default.
- W3136345567 cites W2024513455 @default.
- W3136345567 cites W2025144653 @default.
- W3136345567 cites W2026517372 @default.
- W3136345567 cites W2026712007 @default.
- W3136345567 cites W2029217292 @default.
- W3136345567 cites W2029269187 @default.
- W3136345567 cites W2033281361 @default.
- W3136345567 cites W2035907345 @default.
- W3136345567 cites W2036110908 @default.
- W3136345567 cites W2036354096 @default.
- W3136345567 cites W2036898640 @default.
- W3136345567 cites W2038142268 @default.
- W3136345567 cites W2041076630 @default.
- W3136345567 cites W2041300026 @default.
- W3136345567 cites W2041304503 @default.
- W3136345567 cites W2041946854 @default.
- W3136345567 cites W2043295482 @default.
- W3136345567 cites W2046163489 @default.
- W3136345567 cites W2046970849 @default.
- W3136345567 cites W2048920872 @default.
- W3136345567 cites W2049491272 @default.
- W3136345567 cites W2049621216 @default.
- W3136345567 cites W2051410387 @default.
- W3136345567 cites W2051691075 @default.
- W3136345567 cites W2052947703 @default.
- W3136345567 cites W2054123592 @default.
- W3136345567 cites W2054801886 @default.
- W3136345567 cites W2058333934 @default.