FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136348482> ?p ?o ?g. }

• W3136348482 abstract "Triple negative breast cancer (TNBC) accounts for about a fifth of all breast cancers and includes a diverse group of cancers. The heterogeneity of TNBC and the lack of target receptors on the cell surface make it difficult to develop specific therapeutic treatments. These aspects cause the high negative prognosis of patients with this type of tumor. The analysis of the molecular profiles of TNBC samples has allowed a better characterization of this tumor, supporting the search for new reliable diagnostic markers. To this end, we have developed a bioinformatic approach to integrate networks of genes differentially expressed in basal breast cancer compared to healthy tissues, with miRNAs able to regulate their expression. We studied the role of these miRNAs in TNBC subtype cell lines. We therefore identified two miRNAs, namely miR-135b and miR-365, with a central role in regulating the altered functional pathways in basal breast cancer. These two miRNAs are differentially expressed in human TNBC immunohistochemistry-selected tissues, and their modulation has been shown to play a role in the proliferation of tumor control and its migratory and invasive capacity in TNBC subtype cell lines. From the perspective of personalized medicine, we managed to modulate the expression of the two miRNAs in organotypic cultures, suggesting their possible use as diagnostic and therapeutic molecules. miR-135b and miR-365 have a key role in TNBC, controlling proliferation and invasion. Their detection could be helpful in TNBC diagnosis, while their modulation could become a new therapeutic tool for TNBC." @default.
• W3136348482 created "2021-03-29" @default.
• W3136348482 creator A5007639428 @default.
• W3136348482 creator A5011081052 @default.
• W3136348482 creator A5016736727 @default.
• W3136348482 creator A5017315290 @default.
• W3136348482 creator A5040229926 @default.
• W3136348482 creator A5042706674 @default.
• W3136348482 creator A5046223372 @default.
• W3136348482 creator A5059245033 @default.
• W3136348482 date "2021-03-22" @default.
• W3136348482 modified "2023-10-15" @default.
• W3136348482 title "Triple negative aggressive phenotype controlled by miR-135b and miR-365: new theranostics candidates" @default.
• W3136348482 cites W1519764726 @default.
• W3136348482 cites W1545095426 @default.
• W3136348482 cites W1789716240 @default.
• W3136348482 cites W1894182713 @default.
• W3136348482 cites W1982166284 @default.
• W3136348482 cites W2077327925 @default.
• W3136348482 cites W2096027508 @default.
• W3136348482 cites W2097255042 @default.
• W3136348482 cites W2117775530 @default.
• W3136348482 cites W2120004516 @default.
• W3136348482 cites W2127421267 @default.
• W3136348482 cites W2131994307 @default.
• W3136348482 cites W2132786809 @default.
• W3136348482 cites W2134539328 @default.
• W3136348482 cites W2139083988 @default.
• W3136348482 cites W2143336748 @default.
• W3136348482 cites W2158627893 @default.
• W3136348482 cites W2162752428 @default.
• W3136348482 cites W2164457061 @default.
• W3136348482 cites W2217061546 @default.
• W3136348482 cites W2230320310 @default.
• W3136348482 cites W2318236079 @default.
• W3136348482 cites W2346752463 @default.
• W3136348482 cites W2404879104 @default.
• W3136348482 cites W2430731787 @default.
• W3136348482 cites W2532987664 @default.
• W3136348482 cites W2551660834 @default.
• W3136348482 cites W2562895910 @default.
• W3136348482 cites W2565206471 @default.
• W3136348482 cites W2575770495 @default.
• W3136348482 cites W2591644378 @default.
• W3136348482 cites W2595109242 @default.
• W3136348482 cites W2745895483 @default.
• W3136348482 cites W2768123142 @default.
• W3136348482 cites W2797246386 @default.
• W3136348482 cites W2806375251 @default.
• W3136348482 cites W2893237431 @default.
• W3136348482 cites W2927232854 @default.
• W3136348482 cites W2963020007 @default.
• W3136348482 cites W2963788253 @default.
• W3136348482 cites W2981815989 @default.
• W3136348482 cites W2982083912 @default.
• W3136348482 cites W2982643118 @default.
• W3136348482 cites W4239051461 @default.
• W3136348482 doi "https://doi.org/10.1038/s41598-021-85746-w" @default.
• W3136348482 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7985188" @default.
• W3136348482 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33753785" @default.
• W3136348482 hasPublicationYear "2021" @default.
• W3136348482 type Work @default.
• W3136348482 sameAs 3136348482 @default.
• W3136348482 citedByCount "7" @default.
• W3136348482 countsByYear W31363484822021 @default.
• W3136348482 countsByYear W31363484822022 @default.
• W3136348482 countsByYear W31363484822023 @default.
• W3136348482 crossrefType "journal-article" @default.
• W3136348482 hasAuthorship W3136348482A5007639428 @default.
• W3136348482 hasAuthorship W3136348482A5011081052 @default.
• W3136348482 hasAuthorship W3136348482A5016736727 @default.
• W3136348482 hasAuthorship W3136348482A5017315290 @default.
• W3136348482 hasAuthorship W3136348482A5040229926 @default.
• W3136348482 hasAuthorship W3136348482A5042706674 @default.
• W3136348482 hasAuthorship W3136348482A5046223372 @default.
• W3136348482 hasAuthorship W3136348482A5059245033 @default.
• W3136348482 hasBestOaLocation W31363484821 @default.
• W3136348482 hasConcept C104317684 @default.
• W3136348482 hasConcept C121608353 @default.
• W3136348482 hasConcept C126322002 @default.
• W3136348482 hasConcept C127716648 @default.
• W3136348482 hasConcept C145059251 @default.
• W3136348482 hasConcept C2778024521 @default.
• W3136348482 hasConcept C2779306644 @default.
• W3136348482 hasConcept C2780110267 @default.
• W3136348482 hasConcept C502942594 @default.
• W3136348482 hasConcept C530470458 @default.
• W3136348482 hasConcept C54355233 @default.
• W3136348482 hasConcept C60644358 @default.
• W3136348482 hasConcept C71924100 @default.
• W3136348482 hasConcept C86803240 @default.
• W3136348482 hasConceptScore W3136348482C104317684 @default.
• W3136348482 hasConceptScore W3136348482C121608353 @default.
• W3136348482 hasConceptScore W3136348482C126322002 @default.
• W3136348482 hasConceptScore W3136348482C127716648 @default.
• W3136348482 hasConceptScore W3136348482C145059251 @default.
• W3136348482 hasConceptScore W3136348482C2778024521 @default.
• W3136348482 hasConceptScore W3136348482C2779306644 @default.
• W3136348482 hasConceptScore W3136348482C2780110267 @default.
• W3136348482 hasConceptScore W3136348482C502942594 @default.

• next