Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136349883> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3136349883 abstract "Primary hyperparathyroidism (pHPT) can be associated with potentially reversible cognitive impairment, which is occasionally mistaken for natural ageing and dementia. The aim was to evaluate short-term medical normalization of hypercalcaemia in surgical decision-making for elderly patients with mild cognitive deficiency.Patients with pHPT were included in a prospective observational study. A test panel including the Montreal Cognitive Assessment (MoCA) and validated tools for estimation of psychological status (Hospital Anxiety and Depression Scale, HADS), and muscle strength (timed-stands test, TST) was applied at baseline, after 4 weeks of calcimimetic treatment, and after parathyroidectomy. Mild cognitive impairment was defined by a MoCA score below 26. A longitudinal increase in MoCA score of at least 2 points 6 months after surgery was considered clinically meaningful.Of 110 patients who underwent testing, 35 aged 50 years or more were identified to have mild cognitive dysfunction, including 19 who were aged at least 70 years (median MoCA score 23, i.q.r. 21-24). Calcimimetic treatment resulted in normalization of calcium levels, and improvements in MoCA and HADS scores, and TST time. Normal MoCA scores (at least 26) were reached in 17 patients by 6 months after surgery, of whom 10 were aged 70 years or older. Long-term increase in MoCA score correlated with the decrease in ionized calcium concentration (r = -0.536, P = 0.022). Baseline calcium concentration and improvement in MoCA with calcimimetic treatment were identified as independent predictors of favourable outcome after parathyroidectomy.Medical normalization of hypercalcaemia can aid in predicting outcome after parathyroidectomy." @default.
- W3136349883 created "2021-03-29" @default.
- W3136349883 creator A5060261986 @default.
- W3136349883 creator A5079771119 @default.
- W3136349883 creator A5079892424 @default.
- W3136349883 creator A5086753064 @default.
- W3136349883 date "2020-12-22" @default.
- W3136349883 modified "2023-10-14" @default.
- W3136349883 title "Prediction of cognitive response to surgery in elderly patients with primary hyperparathyroidism" @default.
- W3136349883 cites W1845447069 @default.
- W3136349883 cites W2010449679 @default.
- W3136349883 cites W2013306705 @default.
- W3136349883 cites W2022792809 @default.
- W3136349883 cites W2038355611 @default.
- W3136349883 cites W2065485957 @default.
- W3136349883 cites W2068606962 @default.
- W3136349883 cites W2084039621 @default.
- W3136349883 cites W2104954752 @default.
- W3136349883 cites W2165758561 @default.
- W3136349883 cites W2166281097 @default.
- W3136349883 cites W2319748538 @default.
- W3136349883 cites W2435764835 @default.
- W3136349883 cites W2499214176 @default.
- W3136349883 cites W2510072409 @default.
- W3136349883 cites W2515002635 @default.
- W3136349883 cites W2556745711 @default.
- W3136349883 cites W2730566961 @default.
- W3136349883 cites W2794115290 @default.
- W3136349883 cites W2979988094 @default.
- W3136349883 cites W3206083345 @default.
- W3136349883 doi "https://doi.org/10.1093/bjsopen/zraa029" @default.
- W3136349883 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7962724" @default.
- W3136349883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33724336" @default.
- W3136349883 hasPublicationYear "2020" @default.
- W3136349883 type Work @default.
- W3136349883 sameAs 3136349883 @default.
- W3136349883 citedByCount "6" @default.
- W3136349883 countsByYear W31363498832022 @default.
- W3136349883 countsByYear W31363498832023 @default.
- W3136349883 crossrefType "journal-article" @default.
- W3136349883 hasAuthorship W3136349883A5060261986 @default.
- W3136349883 hasAuthorship W3136349883A5079771119 @default.
- W3136349883 hasAuthorship W3136349883A5079892424 @default.
- W3136349883 hasAuthorship W3136349883A5086753064 @default.
- W3136349883 hasBestOaLocation W31363498831 @default.
- W3136349883 hasConcept C118552586 @default.
- W3136349883 hasConcept C126322002 @default.
- W3136349883 hasConcept C1862650 @default.
- W3136349883 hasConcept C2776632958 @default.
- W3136349883 hasConcept C2777645128 @default.
- W3136349883 hasConcept C2778739829 @default.
- W3136349883 hasConcept C2778838027 @default.
- W3136349883 hasConcept C2779053571 @default.
- W3136349883 hasConcept C2779134260 @default.
- W3136349883 hasConcept C2779483572 @default.
- W3136349883 hasConcept C2780280601 @default.
- W3136349883 hasConcept C2781208988 @default.
- W3136349883 hasConcept C519063684 @default.
- W3136349883 hasConcept C558461103 @default.
- W3136349883 hasConcept C71924100 @default.
- W3136349883 hasConceptScore W3136349883C118552586 @default.
- W3136349883 hasConceptScore W3136349883C126322002 @default.
- W3136349883 hasConceptScore W3136349883C1862650 @default.
- W3136349883 hasConceptScore W3136349883C2776632958 @default.
- W3136349883 hasConceptScore W3136349883C2777645128 @default.
- W3136349883 hasConceptScore W3136349883C2778739829 @default.
- W3136349883 hasConceptScore W3136349883C2778838027 @default.
- W3136349883 hasConceptScore W3136349883C2779053571 @default.
- W3136349883 hasConceptScore W3136349883C2779134260 @default.
- W3136349883 hasConceptScore W3136349883C2779483572 @default.
- W3136349883 hasConceptScore W3136349883C2780280601 @default.
- W3136349883 hasConceptScore W3136349883C2781208988 @default.
- W3136349883 hasConceptScore W3136349883C519063684 @default.
- W3136349883 hasConceptScore W3136349883C558461103 @default.
- W3136349883 hasConceptScore W3136349883C71924100 @default.
- W3136349883 hasFunder F4320322315 @default.
- W3136349883 hasFunder F4320323741 @default.
- W3136349883 hasFunder F4320325016 @default.
- W3136349883 hasFunder F4320325957 @default.
- W3136349883 hasIssue "2" @default.
- W3136349883 hasLocation W31363498831 @default.
- W3136349883 hasLocation W31363498832 @default.
- W3136349883 hasLocation W31363498833 @default.
- W3136349883 hasOpenAccess W3136349883 @default.
- W3136349883 hasPrimaryLocation W31363498831 @default.
- W3136349883 hasRelatedWork W2029828978 @default.
- W3136349883 hasRelatedWork W2133709292 @default.
- W3136349883 hasRelatedWork W2258216750 @default.
- W3136349883 hasRelatedWork W2397252022 @default.
- W3136349883 hasRelatedWork W2415858577 @default.
- W3136349883 hasRelatedWork W2905158850 @default.
- W3136349883 hasRelatedWork W2945700351 @default.
- W3136349883 hasRelatedWork W2979988094 @default.
- W3136349883 hasRelatedWork W3136349883 @default.
- W3136349883 hasRelatedWork W3146674290 @default.
- W3136349883 hasVolume "5" @default.
- W3136349883 isParatext "false" @default.
- W3136349883 isRetracted "false" @default.
- W3136349883 magId "3136349883" @default.
- W3136349883 workType "article" @default.