FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136351970> ?p ?o ?g. }

• W3136351970 endingPage "175628642199891" @default.
• W3136351970 startingPage "175628642199891" @default.
• W3136351970 abstract "Immune-mediated necrotizing myopathy (IMNM) is a group of immune-related myopathies characterized by progressive proximal muscle weakness, extremely high serum creatine kinase (CK) levels, and necrotic muscle fibers with a relative lack of inflammation. Treatment of IMNM is challenging, with most cases refractory to high-dose steroids in combination with multiple immunotherapies. The role of rituximab (RTX) for IMNM has been explored in isolated case reports and small series. The aim of this article was to perform a literature review of patients with IMNM treated with RTX and to evaluate RTX efficacy and safety. A total of 34 patients with IMNM were reviewed: 52.9% (18/34) with anti-signal recognition particle (SRP) antibodies and 47.1% (16/34) with anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) antibodies. Patient age at onset varied from 11 years to 81 years (mean 41 years). The majority of patients presented as a severe proximal muscle weakness and the peak level of CK varied from 3900 IU/L to 56,000 IU/L (mean 18,440 IU/L). Prior to RTX administration, all patients were treated with high-dose steroids and most were treated with multiple immunotherapies. The reason for initiating RTX was that 64.7% (22/34) of patients showed no improvement after previous treatments, and 35.3% (12/34) of patients relapsed when attempting to wean steroids or other immunosuppressive agents. With regard to RTX efficacy, 61.8% (21/34) of patients presented a response to RTX. Our data may support the use of RTX as an effective treatment strategy against IMNM resistant to steroids and multiple immunotherapies. Meanwhile, RTX as a first-line therapy could be a choice in IMNM, particularly in African Americans with anti-SRP antibody-positive subsets. ANA, antinuclear antibody; CK, creatine kinase; HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase; IMNM, immune-mediated necrotizing myopathy; MAC, membrane attack complex; MHC-I, major histocompatibility complex-I; RTX, rituximab; SRP, signal recognition particle." @default.
• W3136351970 created "2021-03-29" @default.
• W3136351970 creator A5029787620 @default.
• W3136351970 creator A5037797754 @default.
• W3136351970 creator A5041620414 @default.
• W3136351970 creator A5061849555 @default.
• W3136351970 creator A5064599095 @default.
• W3136351970 creator A5070517216 @default.
• W3136351970 creator A5075088465 @default.
• W3136351970 creator A5080792603 @default.
• W3136351970 creator A5086556992 @default.
• W3136351970 creator A5090948350 @default.
• W3136351970 date "2021-01-01" @default.
• W3136351970 modified "2023-10-16" @default.
• W3136351970 title "Rituximab in the treatment of immune-mediated necrotizing myopathy: a review of case reports and case series" @default.
• W3136351970 cites W1911783194 @default.
• W3136351970 cites W1973063062 @default.
• W3136351970 cites W1980821042 @default.
• W3136351970 cites W1982008427 @default.
• W3136351970 cites W2007540726 @default.
• W3136351970 cites W2010335787 @default.
• W3136351970 cites W2016955385 @default.
• W3136351970 cites W2018803381 @default.
• W3136351970 cites W2031973282 @default.
• W3136351970 cites W2059998793 @default.
• W3136351970 cites W2076417190 @default.
• W3136351970 cites W2088121511 @default.
• W3136351970 cites W2103541256 @default.
• W3136351970 cites W2148920525 @default.
• W3136351970 cites W2154394042 @default.
• W3136351970 cites W2155242388 @default.
• W3136351970 cites W2159985097 @default.
• W3136351970 cites W2163226208 @default.
• W3136351970 cites W2163461328 @default.
• W3136351970 cites W2166714841 @default.
• W3136351970 cites W2170896558 @default.
• W3136351970 cites W2514439344 @default.
• W3136351970 cites W2598337844 @default.
• W3136351970 cites W2743653021 @default.
• W3136351970 cites W2765714778 @default.
• W3136351970 cites W2766028155 @default.
• W3136351970 cites W2783410073 @default.
• W3136351970 cites W2897506614 @default.
• W3136351970 cites W2904102251 @default.
• W3136351970 cites W2936277541 @default.
• W3136351970 cites W2940531398 @default.
• W3136351970 cites W2970919491 @default.
• W3136351970 cites W2981502040 @default.
• W3136351970 cites W2993345821 @default.
• W3136351970 cites W3006646555 @default.
• W3136351970 cites W3007185188 @default.
• W3136351970 cites W3008372023 @default.
• W3136351970 cites W2804077024 @default.
• W3136351970 doi "https://doi.org/10.1177/1756286421998918" @default.
• W3136351970 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7958167" @default.
• W3136351970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33786066" @default.
• W3136351970 hasPublicationYear "2021" @default.
• W3136351970 type Work @default.
• W3136351970 sameAs 3136351970 @default.
• W3136351970 citedByCount "5" @default.
• W3136351970 countsByYear W31363519702021 @default.
• W3136351970 countsByYear W31363519702022 @default.
• W3136351970 countsByYear W31363519702023 @default.
• W3136351970 crossrefType "journal-article" @default.
• W3136351970 hasAuthorship W3136351970A5029787620 @default.
• W3136351970 hasAuthorship W3136351970A5037797754 @default.
• W3136351970 hasAuthorship W3136351970A5041620414 @default.
• W3136351970 hasAuthorship W3136351970A5061849555 @default.
• W3136351970 hasAuthorship W3136351970A5064599095 @default.
• W3136351970 hasAuthorship W3136351970A5070517216 @default.
• W3136351970 hasAuthorship W3136351970A5075088465 @default.
• W3136351970 hasAuthorship W3136351970A5080792603 @default.
• W3136351970 hasAuthorship W3136351970A5086556992 @default.
• W3136351970 hasAuthorship W3136351970A5090948350 @default.
• W3136351970 hasBestOaLocation W31363519701 @default.
• W3136351970 hasConcept C126322002 @default.
• W3136351970 hasConcept C141071460 @default.
• W3136351970 hasConcept C159654299 @default.
• W3136351970 hasConcept C203014093 @default.
• W3136351970 hasConcept C2776418732 @default.
• W3136351970 hasConcept C2777300911 @default.
• W3136351970 hasConcept C2780247198 @default.
• W3136351970 hasConcept C2780653079 @default.
• W3136351970 hasConcept C36880943 @default.
• W3136351970 hasConcept C71924100 @default.
• W3136351970 hasConcept C8891405 @default.
• W3136351970 hasConcept C90924648 @default.
• W3136351970 hasConceptScore W3136351970C126322002 @default.
• W3136351970 hasConceptScore W3136351970C141071460 @default.
• W3136351970 hasConceptScore W3136351970C159654299 @default.
• W3136351970 hasConceptScore W3136351970C203014093 @default.
• W3136351970 hasConceptScore W3136351970C2776418732 @default.
• W3136351970 hasConceptScore W3136351970C2777300911 @default.
• W3136351970 hasConceptScore W3136351970C2780247198 @default.
• W3136351970 hasConceptScore W3136351970C2780653079 @default.
• W3136351970 hasConceptScore W3136351970C36880943 @default.
• W3136351970 hasConceptScore W3136351970C71924100 @default.
• W3136351970 hasConceptScore W3136351970C8891405 @default.

• next