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- W3136352227 startingPage "37" @default.
- W3136352227 abstract "Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer and has seen only modest improvements in patient survival rate over the past few decades. PDAC is highly aggressive and resistant to chemotherapy, owing to the presence of a dense and hypovascularized fibrotic tissue, which is composed of stromal cells and extracellular matrices. Increase deposition and crosslinking of matrices by stromal cells lead to a heterogeneous microenvironment that aids in PDAC development. In the past decade, various hydrogel-based, in vitro tumor models have been developed to mimic and recapitulate aspects of the tumor microenvironment in PDAC. Advances in hydrogel chemistry and engineering should provide a venue for discovering new insights regarding how matrix properties govern PDAC cell growth, migration, invasion, and drug resistance. These engineered hydrogels are ideal for understanding how variation in matrix properties contributes to the progressiveness of cancer cells, including durotaxis, the directional migration of cells in response to a stiffness gradient. This review surveys the various hydrogel-based, in vitro tumor models and the methods to generate gradient stiffness for studying migration and other cancer cell fate processes in PDAC." @default.
- W3136352227 created "2021-03-29" @default.
- W3136352227 creator A5019613511 @default.
- W3136352227 creator A5086989917 @default.
- W3136352227 date "2021-03-13" @default.
- W3136352227 modified "2023-10-14" @default.
- W3136352227 title "Hydrogel Models with Stiffness Gradients for Interrogating Pancreatic Cancer Cell Fate" @default.
- W3136352227 cites W1426710699 @default.
- W3136352227 cites W1861257336 @default.
- W3136352227 cites W1876879565 @default.
- W3136352227 cites W1947523479 @default.
- W3136352227 cites W1964032218 @default.
- W3136352227 cites W1977381126 @default.
- W3136352227 cites W1996912024 @default.
- W3136352227 cites W2002516695 @default.
- W3136352227 cites W2012119502 @default.
- W3136352227 cites W2018810555 @default.
- W3136352227 cites W2020780267 @default.
- W3136352227 cites W2023026872 @default.
- W3136352227 cites W2023392633 @default.
- W3136352227 cites W2023952099 @default.
- W3136352227 cites W2024250498 @default.
- W3136352227 cites W2030233835 @default.
- W3136352227 cites W2033878276 @default.
- W3136352227 cites W2049132016 @default.
- W3136352227 cites W2055091294 @default.
- W3136352227 cites W2055624262 @default.
- W3136352227 cites W2055880222 @default.
- W3136352227 cites W2055919941 @default.
- W3136352227 cites W2058533949 @default.
- W3136352227 cites W2060066380 @default.
- W3136352227 cites W2062929087 @default.
- W3136352227 cites W2066135299 @default.
- W3136352227 cites W2069518226 @default.
- W3136352227 cites W2077428167 @default.
- W3136352227 cites W2081910439 @default.
- W3136352227 cites W2086310075 @default.
- W3136352227 cites W2087771736 @default.
- W3136352227 cites W2088812649 @default.
- W3136352227 cites W2094124163 @default.
- W3136352227 cites W2103883318 @default.
- W3136352227 cites W2104077231 @default.
- W3136352227 cites W2106324055 @default.
- W3136352227 cites W2106603160 @default.
- W3136352227 cites W2109259166 @default.
- W3136352227 cites W2110947634 @default.
- W3136352227 cites W2112254361 @default.
- W3136352227 cites W2118952409 @default.
- W3136352227 cites W2126044151 @default.
- W3136352227 cites W2126531317 @default.
- W3136352227 cites W2126663928 @default.
- W3136352227 cites W2130229338 @default.
- W3136352227 cites W2131328415 @default.
- W3136352227 cites W2134208433 @default.
- W3136352227 cites W2134709252 @default.
- W3136352227 cites W2136280424 @default.
- W3136352227 cites W2139234903 @default.
- W3136352227 cites W2140814324 @default.
- W3136352227 cites W2150690284 @default.
- W3136352227 cites W2150751366 @default.
- W3136352227 cites W2156056478 @default.
- W3136352227 cites W2156365755 @default.
- W3136352227 cites W2161831994 @default.
- W3136352227 cites W2165480504 @default.
- W3136352227 cites W2168979411 @default.
- W3136352227 cites W2170202192 @default.
- W3136352227 cites W2259823352 @default.
- W3136352227 cites W2280422486 @default.
- W3136352227 cites W2292016096 @default.
- W3136352227 cites W2307633579 @default.
- W3136352227 cites W2326081342 @default.
- W3136352227 cites W2339372785 @default.
- W3136352227 cites W2343973378 @default.
- W3136352227 cites W2345162663 @default.
- W3136352227 cites W2396664928 @default.
- W3136352227 cites W2410628036 @default.
- W3136352227 cites W2416037803 @default.
- W3136352227 cites W2435165070 @default.
- W3136352227 cites W2460593466 @default.
- W3136352227 cites W2476542314 @default.
- W3136352227 cites W2535780998 @default.
- W3136352227 cites W2547875537 @default.
- W3136352227 cites W2550160158 @default.
- W3136352227 cites W2553667461 @default.
- W3136352227 cites W2554304258 @default.
- W3136352227 cites W2559899567 @default.
- W3136352227 cites W2588279759 @default.
- W3136352227 cites W2590146273 @default.
- W3136352227 cites W2616779259 @default.
- W3136352227 cites W2618391571 @default.
- W3136352227 cites W2726164542 @default.
- W3136352227 cites W2730718150 @default.
- W3136352227 cites W2742841087 @default.
- W3136352227 cites W2744685611 @default.
- W3136352227 cites W2750853956 @default.
- W3136352227 cites W2756399930 @default.
- W3136352227 cites W2762514399 @default.
- W3136352227 cites W2775638497 @default.