FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136358399> ?p ?o ?g. }

• W3136358399 endingPage "2093" @default.
• W3136358399 startingPage "2072" @default.
• W3136358399 abstract "Clear cell renal cell carcinoma (ccRCC) is characterized by accumulation of neutral lipids and adipogenic transdifferentiation. We assessed adipokine expression in ccRCC and found that tumor tissues and patient plasma exhibit obesity-dependent elevations of the adipokine chemerin. Attenuation of chemerin by several approaches led to significant reduction in lipid deposition and impairment of tumor cell growth in vitro and in vivo. A multi-omics approach revealed that chemerin suppresses fatty acid oxidation, preventing ferroptosis, and maintains fatty acid levels that activate hypoxia-inducible factor 2α expression. The lipid coenzyme Q and mitochondrial complex IV, whose biogeneses are lipid-dependent, were found to be decreased after chemerin inhibition, contributing to lipid reactive oxygen species production. Monoclonal antibody targeting chemerin led to reduced lipid storage and diminished tumor growth, demonstrating translational potential of chemerin inhibition. Collectively, the results suggest that obesity and tumor cells contribute to ccRCC through the expression of chemerin, which is indispensable in ccRCC biology. SIGNIFICANCE: Identification of a hypoxia-inducible factor-dependent adipokine that prevents fatty acid oxidation and causes escape from ferroptosis highlights a critical metabolic dependency unique in the clear cell subtype of kidney cancer. Targeting lipid metabolism via inhibition of a soluble factor is a promising pharmacologic approach to expand therapeutic strategies for patients with ccRCC.See related commentary by Reznik et al., p. 1879.This article is highlighted in the In This Issue feature, p. 1861." @default.
• W3136358399 created "2021-03-29" @default.
• W3136358399 creator A5000564724 @default.
• W3136358399 creator A5001893412 @default.
• W3136358399 creator A5005721937 @default.
• W3136358399 creator A5010665082 @default.
• W3136358399 creator A5017806941 @default.
• W3136358399 creator A5021890259 @default.
• W3136358399 creator A5028524295 @default.
• W3136358399 creator A5048696956 @default.
• W3136358399 creator A5051682378 @default.
• W3136358399 creator A5063835480 @default.
• W3136358399 creator A5079381232 @default.
• W3136358399 creator A5089163662 @default.
• W3136358399 creator A5091731877 @default.
• W3136358399 date "2021-03-23" @default.
• W3136358399 modified "2023-10-14" @default.
• W3136358399 title "Obesity-Dependent Adipokine Chemerin Suppresses Fatty Acid Oxidation to Confer Ferroptosis Resistance" @default.
• W3136358399 cites W1484884192 @default.
• W3136358399 cites W1509983325 @default.
• W3136358399 cites W1556836946 @default.
• W3136358399 cites W1602006689 @default.
• W3136358399 cites W1906260222 @default.
• W3136358399 cites W1945321984 @default.
• W3136358399 cites W1988377666 @default.
• W3136358399 cites W1989299822 @default.
• W3136358399 cites W1995541025 @default.
• W3136358399 cites W1998554884 @default.
• W3136358399 cites W2027542963 @default.
• W3136358399 cites W2030691386 @default.
• W3136358399 cites W2046658835 @default.
• W3136358399 cites W2047666011 @default.
• W3136358399 cites W2054167577 @default.
• W3136358399 cites W2091783958 @default.
• W3136358399 cites W2099597821 @default.
• W3136358399 cites W2106705118 @default.
• W3136358399 cites W2108453042 @default.
• W3136358399 cites W2110139358 @default.
• W3136358399 cites W2114104545 @default.
• W3136358399 cites W2119314929 @default.
• W3136358399 cites W2123106337 @default.
• W3136358399 cites W2130410032 @default.
• W3136358399 cites W2132767601 @default.
• W3136358399 cites W2135546443 @default.
• W3136358399 cites W2147634065 @default.
• W3136358399 cites W2168015220 @default.
• W3136358399 cites W2168526937 @default.
• W3136358399 cites W2169456326 @default.
• W3136358399 cites W2171628789 @default.
• W3136358399 cites W2297048307 @default.
• W3136358399 cites W2622954435 @default.
• W3136358399 cites W2734782517 @default.
• W3136358399 cites W2763572134 @default.
• W3136358399 cites W2768435200 @default.
• W3136358399 cites W2791549657 @default.
• W3136358399 cites W2794372989 @default.
• W3136358399 cites W2794480084 @default.
• W3136358399 cites W2803033229 @default.
• W3136358399 cites W2803865599 @default.
• W3136358399 cites W2806924362 @default.
• W3136358399 cites W2811408032 @default.
• W3136358399 cites W2887326710 @default.
• W3136358399 cites W2891350075 @default.
• W3136358399 cites W2891967018 @default.
• W3136358399 cites W2902283448 @default.
• W3136358399 cites W2903553908 @default.
• W3136358399 cites W2906933945 @default.
• W3136358399 cites W2911188335 @default.
• W3136358399 cites W2916610971 @default.
• W3136358399 cites W2916992870 @default.
• W3136358399 cites W2919048656 @default.
• W3136358399 cites W2943893201 @default.
• W3136358399 cites W2945220204 @default.
• W3136358399 cites W2949177718 @default.
• W3136358399 cites W2954662313 @default.
• W3136358399 cites W2972164676 @default.
• W3136358399 cites W2975383676 @default.
• W3136358399 cites W2980472864 @default.
• W3136358399 cites W2989385987 @default.
• W3136358399 cites W2993865487 @default.
• W3136358399 cites W2995298233 @default.
• W3136358399 cites W2995834243 @default.
• W3136358399 cites W3000163249 @default.
• W3136358399 cites W3008177203 @default.
• W3136358399 cites W3008934493 @default.
• W3136358399 cites W3009805001 @default.
• W3136358399 cites W3009846508 @default.
• W3136358399 cites W3009992544 @default.
• W3136358399 cites W3012292768 @default.
• W3136358399 cites W3025451213 @default.
• W3136358399 cites W3081351270 @default.
• W3136358399 doi "https://doi.org/10.1158/2159-8290.cd-20-1453" @default.
• W3136358399 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8338847" @default.
• W3136358399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33757970" @default.
• W3136358399 hasPublicationYear "2021" @default.
• W3136358399 type Work @default.
• W3136358399 sameAs 3136358399 @default.
• W3136358399 citedByCount "33" @default.

• next