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- W3136358430 abstract "Sporadic Creutzfeldt-Jacob disease(sCJD)is a prion disease presenting with subacute or rapidly progressive dementia with a poor prognosis. Asymmetrical cortical lesions with thalamic involvement are found in sCJD cases, which is similar distribution to status epileptics, but the lesions are not observed in the limbic systems, and they rarely occur in the precentral gyrus. Characteristically, hyperintense abnormal findings are more prominent on DWI than on FLAIR and T2WI. 19.9% of CJD is genetic CJD(gCJD), and CJD with a mutation of codon 180 from valine to isoleucine(V180I)accounts for 40% of gCJD in Japan. Patients with this type of gCJD rarely have a family history because of the low penetration rate. The age of onset is usually later, and its clinical symptoms deteriorate more slowly than sCJD. DWI shows abnormal cortical hyperintense signals(cortical ribboning)." @default.
- W3136358430 created "2021-03-29" @default.
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- W3136358430 date "2021-03-01" @default.
- W3136358430 modified "2023-09-22" @default.
- W3136358430 title "[Creutzfeldt-Jakob Disease]." @default.
- W3136358430 doi "https://doi.org/10.11477/mf.1436204406" @default.
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