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- W3136359971 startingPage "102400" @default.
- W3136359971 abstract "Cancer is the second leading cause of death worldwide and accounted for an estimated 9.6 million deaths, or 1 in 6 deaths, in 2018. Despite recent advances in cancer prevention, diagnosis, and treatment strategies, the burden of this disease continues to grow with each year, with dire physical, emotional, and economic consequences for all levels of society. Classic characteristics of cancer include rapid, uncontrolled cell proliferation and spread of cancerous cells to other parts of the body, a process known as metastasis. Transient receptor potential melastatin 7 (TRPM7), a Ca2+- and Mg2+-permeable nonselective divalent cation channel defined by the atypical presence of an α-kinase within its C-terminal domain, has been implicated, due to its modulation of Ca2+ and Mg2+ influx, in a wide variety of physiological and pathological processes, including cancer. TRPM7 is overexpressed in several cancer types and has been shown to variably increase cellular proliferation, migration, and invasion of tumour cells. However, the relative contribution of TRPM7 kinase domain activity to cancer as opposed to ion flux through its channel pore remains an area of active discovery. In this review, we describe the specific role of the TRPM7 kinase domain in cancer processes as well as mechanisms of regulation and inhibition of the kinase domain." @default.
- W3136359971 created "2021-03-29" @default.
- W3136359971 creator A5008724157 @default.
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- W3136359971 creator A5054420556 @default.
- W3136359971 creator A5059521493 @default.
- W3136359971 creator A5064410327 @default.
- W3136359971 creator A5071323598 @default.
- W3136359971 creator A5084699483 @default.
- W3136359971 date "2021-06-01" @default.
- W3136359971 modified "2023-10-14" @default.
- W3136359971 title "Role of TRPM7 kinase in cancer" @default.
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