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• W3136365789 abstract "Summary Bacteria must balance the different needs for substrate assimilation, growth functions, and resilience in order to thrive in their environment. Of all cellular macromolecules, the bacterial proteome is by far the most important resource and its size is limited. Here, we investigated how the highly versatile ’knallgas’ bacterium Cupriavidus necator reallocates protein resources when grown on different limiting substrates and with different growth rates. We determined protein quantity by mass spectrometry and estimated enzyme utilization by resource balance analysis modeling. We found that C. necator invests a large fraction of its proteome in functions that are hardly utilized. Of the enzymes that are utilized, many are present in excess abundance. One prominent example is the strong expression of CBB cycle genes such as Rubisco during growth on fructose. Modeling and mutant competition experiments suggest that CO 2 -reassimilation through Rubisco does not provide a fitness benefit for heterotrophic growth, but is rather an investment in readiness for autotrophy. Highlights A large fraction of the C. necator proteome is related to environmental readiness Highly utilized enzymes are more abundant and less variable Autotrophy related enzymes are largely underutilized Re-assimilation of CO 2 via CBB cycle does not provide a fitness benefit on sugars" @default.
• W3136365789 created "2021-03-29" @default.
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• W3136365789 date "2021-03-22" @default.
• W3136365789 modified "2023-09-30" @default.
• W3136365789 title "Protein allocation and utilization in the versatile chemolithoautotroph Cupriavidus necator" @default.
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• W3136365789 doi "https://doi.org/10.1101/2021.03.21.436304" @default.
• W3136365789 hasPublicationYear "2021" @default.
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