FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136366611> ?p ?o ?g. }

• W3136366611 abstract "Abstract MicroRNAs (miRNAs) are involved in healthy B cell responses and the loss of tolerance in systemic lupus erythematosus (SLE), though the role of many miRNAs remains poorly understood. Dampening miR-21 activity was previously shown to reduce splenomegaly and blood urea nitrogen levels in SLE-prone mice, but the detailed cellular responses and mechanism of action remains unexplored. Herein, using the TLR7 agonist imiquimod-induced SLE model, we observed that loss of miR-21 in Sle1b mice prevented the formation of plasma cells and autoantibody forming cells (AFC), without a significant effect on the magnitude of the germinal center (GC) response. We further observed reduced dendritic cell and monocyte numbers in the spleens of miR-21 deficient Sle1b ( Sle1b .miR-21KO) mice that were associated with reduced interferon, proinflammatory cytokines, and effector CD4 + T cell responses. RNAseq analysis on B cells from Sle1b .miR-21KO mice revealed reduced activation and response to interferon and cytokine and target array analysis revealed modulation of numerous miR-21 target genes in response to TLR7 activation and type I interferon stimulation. Our findings in the B6. Sle1b .Yaa spontaneous model recapitulated the miR-21 role in TLR7-induced responses with an additional role in autoimmune GC and Tfh responses. Finally, immunization with T-dependent antigen revealed a role for miR-21 in foreign antigen driven GC and Ab, but not AFC responses. Our data suggest a potential multifaceted, context-dependent role for miR-21 in autoimmune and foreign antigen driven AFC and GC responses. Further study is warranted to delineate the cell-intrinsic requirements and mechanisms of miR-21 during infection and SLE development. Key Points miR-21 has context dependent effects on AFC and GC responses miR-21 promotes TLR7-driven autoimmunity with activation of multiple B cell pathways miR-21 is required for optimal B cell responses to T-dependent foreign antigen" @default.
• W3136366611 created "2021-03-29" @default.
• W3136366611 creator A5004491636 @default.
• W3136366611 creator A5007290314 @default.
• W3136366611 creator A5024095896 @default.
• W3136366611 creator A5024150887 @default.
• W3136366611 creator A5026909486 @default.
• W3136366611 creator A5050390918 @default.
• W3136366611 creator A5059384437 @default.
• W3136366611 creator A5077289252 @default.
• W3136366611 creator A5082587122 @default.
• W3136366611 creator A5084650124 @default.
• W3136366611 date "2021-03-13" @default.
• W3136366611 modified "2023-10-06" @default.
• W3136366611 title "Context-dependent miR-21 regulation of TLR7-mediated autoimmune and foreign antigen driven antibody-forming cell and germinal center responses" @default.
• W3136366611 cites W1492230630 @default.
• W3136366611 cites W1958716837 @default.
• W3136366611 cites W1963149729 @default.
• W3136366611 cites W1963818196 @default.
• W3136366611 cites W1966054625 @default.
• W3136366611 cites W1986925279 @default.
• W3136366611 cites W1990312329 @default.
• W3136366611 cites W1997865382 @default.
• W3136366611 cites W2015054805 @default.
• W3136366611 cites W2016499233 @default.
• W3136366611 cites W2034528584 @default.
• W3136366611 cites W2036534625 @default.
• W3136366611 cites W2039301616 @default.
• W3136366611 cites W2043263210 @default.
• W3136366611 cites W2046032039 @default.
• W3136366611 cites W2060407329 @default.
• W3136366611 cites W2079294041 @default.
• W3136366611 cites W2080727065 @default.
• W3136366611 cites W2081133146 @default.
• W3136366611 cites W2081416658 @default.
• W3136366611 cites W2089856053 @default.
• W3136366611 cites W2094050516 @default.
• W3136366611 cites W2096323879 @default.
• W3136366611 cites W2096407919 @default.
• W3136366611 cites W2098199767 @default.
• W3136366611 cites W2103017472 @default.
• W3136366611 cites W2107765174 @default.
• W3136366611 cites W2110528006 @default.
• W3136366611 cites W2110756892 @default.
• W3136366611 cites W2113932056 @default.
• W3136366611 cites W2118139916 @default.
• W3136366611 cites W2118842534 @default.
• W3136366611 cites W2123901710 @default.
• W3136366611 cites W2127586500 @default.
• W3136366611 cites W2134106169 @default.
• W3136366611 cites W2135507348 @default.
• W3136366611 cites W2136854370 @default.
• W3136366611 cites W2138684248 @default.
• W3136366611 cites W2139605631 @default.
• W3136366611 cites W2141875386 @default.
• W3136366611 cites W2147449671 @default.
• W3136366611 cites W2148749566 @default.
• W3136366611 cites W2152891840 @default.
• W3136366611 cites W2153522676 @default.
• W3136366611 cites W2158399905 @default.
• W3136366611 cites W2158939366 @default.
• W3136366611 cites W2170801676 @default.
• W3136366611 cites W2287188530 @default.
• W3136366611 cites W2303914852 @default.
• W3136366611 cites W2323307238 @default.
• W3136366611 cites W2324116468 @default.
• W3136366611 cites W2439580280 @default.
• W3136366611 cites W2586925874 @default.
• W3136366611 cites W2588025094 @default.
• W3136366611 cites W2608857446 @default.
• W3136366611 cites W2737017044 @default.
• W3136366611 cites W2754869002 @default.
• W3136366611 cites W2755000263 @default.
• W3136366611 cites W2767426721 @default.
• W3136366611 cites W2789701609 @default.
• W3136366611 cites W2794030130 @default.
• W3136366611 cites W2817337970 @default.
• W3136366611 cites W2825313082 @default.
• W3136366611 cites W2836931367 @default.
• W3136366611 cites W2899501602 @default.
• W3136366611 cites W2899756458 @default.
• W3136366611 cites W2950595506 @default.
• W3136366611 cites W2997087943 @default.
• W3136366611 cites W4292232933 @default.
• W3136366611 doi "https://doi.org/10.1101/2021.03.12.435182" @default.
• W3136366611 hasPublicationYear "2021" @default.
• W3136366611 type Work @default.
• W3136366611 sameAs 3136366611 @default.
• W3136366611 citedByCount "1" @default.
• W3136366611 countsByYear W31363666112021 @default.
• W3136366611 crossrefType "posted-content" @default.
• W3136366611 hasAuthorship W3136366611A5004491636 @default.
• W3136366611 hasAuthorship W3136366611A5007290314 @default.
• W3136366611 hasAuthorship W3136366611A5024095896 @default.
• W3136366611 hasAuthorship W3136366611A5024150887 @default.
• W3136366611 hasAuthorship W3136366611A5026909486 @default.
• W3136366611 hasAuthorship W3136366611A5050390918 @default.
• W3136366611 hasAuthorship W3136366611A5059384437 @default.
• W3136366611 hasAuthorship W3136366611A5077289252 @default.
• W3136366611 hasAuthorship W3136366611A5082587122 @default.

• next