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• W3136366996 abstract "3070 Objectives: Prior to 2018, the institution where my research was performed used only 18F-FDG to detect cardiac sarcoidosis. With the addition of 13N ammonia, the cost of testing increased due to billing out two procedures, one for the 18F-FDG imaging and one for the 13N ammonia imaging. Therefore, the purpose of this study is to determine how often 13N ammonia is effective in helping diagnose patients with cardiac sarcoidosis. Background: 18F-FDG is used to detect cardiac sarcoidosis due to its ability to image inflammation. By quantifying the inflammation, 18F-FDG is useful for assessing treatment response and informing decisions on duration, intensity, or choice of therapy. When combined with 13N ammonia, perfusion defects due to cardiac sarcoidosis can be visualized. Perfusion defects are either caused by scarring or compression of the microvasculature due to the inflammation. In the instance of scarring, a perfusion defect is seen without any 18F-FDG uptake present. On the other hand, when the microvasculature is compressed, a perfusion defect is seen along with the uptake of 18F-FDG1. Methods: A retrospective study was done on 59 scans. Each scan was examined and results were recorded based on positive findings for increased 18F-FDG uptake as well as positive findings for 13N ammonia perfusion defects. Statistical sensitivity tests were then performed to analyze the data. Results: It was found that 26 out of 59 scans had positive findings for 18F-FDG uptake. Of those 26 scans, eight (31%) had positive findings for 13N ammonia perfusion defects. Additionally, there were two scans that had 13N ammonia perfusion defects but no correlating 18F-FDG uptake. Conclusion: Overall, 31% of patients with noted 18F-FDG uptake had correlating 13N ammonia perfusion defects. This correlation helps in the staging and treatment planning of cardiac sarcoidosis. The two scans that showed 13N ammonia perfusion defects without correlating 18F-FDG uptake were due to scarring. However, without prior imaging it cannot be determined if the scarring was due to sarcoidosis. 13N ammonia is aiding in the diagnosis of cardiac sarcoidosis, and our physicians believe it is the standard of care for patients with sarcoidosis. Institutions should continue using 13N ammonia along with 18F-FDG for all patients with cardiac sarcoidosis." @default.
• W3136366996 created "2021-03-29" @default.
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• W3136366996 date "2020-05-01" @default.
• W3136366996 modified "2023-09-26" @default.
• W3136366996 title "Effectiveness of 13N ammonia in aiding in the detection of cardiac sarcoidosis" @default.
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