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• W3136369050 abstract "MicroRNAs (miRNAs) are a class of highly conserved, endogenous non-coding single-stranded small RNA molecules with a length of 18–25 nucleotides. MiRNAs can negatively regulate the target gene through complementary pairing with the mRNA. It has been more than 20 years since the discovery of miRNA molecules, and many achievements have been made in fish research. This paper reviews the research progress in the regulation of fish nutrition and immunity by miRNAs in recent years. MiRNAs regulate the synthesis of long-chain polyunsaturated fatty acids, and are involved in the metabolism of glucose, lipids, as well as cholesterol in fish. Moreover, miRNAs play various roles in antibacterial and antiviral immunity of fish. They can promote the immune response of fish, but may also participate in the immune escape mechanism of bacteria or viruses. One important aspect of miRNAs regulation on fish immunity is mediated by targeting pattern recognition receptors and downstream signaling factors. Together, current results indicate that miRNAs are widely involved in the complex regulatory network of fish. Further studies on fish miRNAs may deepen our understanding of the regulatory network of fish nutrition and immunity, and have the potential to promote the development of microRNA-based products and detection reagents that can be applied in aquaculture industry." @default.
• W3136369050 created "2021-03-29" @default.
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• W3136369050 date "2021-06-01" @default.
• W3136369050 modified "2023-09-29" @default.
• W3136369050 title "Research progress on the regulation of nutrition and immunity by microRNAs in fish" @default.
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• W3136369050 doi "https://doi.org/10.1016/j.fsi.2021.03.011" @default.
• W3136369050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33766547" @default.

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