Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136372277> ?p ?o ?g. }
- W3136372277 abstract "Abstract Our current quantitative knowledge of the kinetics of antibody-mediated immunity is partly based on idealized experiments throughout the last decades. However, new experimental techniques often render contradictory quantitative outcomes that shake previously uncontroversial assumptions. This has been the case in the field of T-cell receptors, where recent techniques for measuring the 2-dimensional rate constants of T-cell receptor-ligand interactions exposed contradictory results to those obtained with techniques measuring 3-dimensional interactions. Recently, we have developed a mathematical framework to rationalize those discrepancies focusing on the proper fine-grained description of the underlying kinetic steps involved in the immune synapse. In this perspective article, we apply this approach to unveil potential blind spots in the case of B-cell receptors (BCR) and to rethink the interactions between B cells and follicular dendritic cells (FDC) during the germinal center (GC) reaction. Also, we elaborate on the concept of “catch bonds” and on the recent observations that B-cell synapses retract and pull antigen generating a “retracting force”, and propose some testable predictions that can lead to future research." @default.
- W3136372277 created "2021-03-29" @default.
- W3136372277 creator A5002816287 @default.
- W3136372277 creator A5056874233 @default.
- W3136372277 date "2021-03-12" @default.
- W3136372277 modified "2023-09-23" @default.
- W3136372277 title "Affinity selection in germinal centers: Cautionary tales and new opportunities" @default.
- W3136372277 cites W1537236879 @default.
- W3136372277 cites W1543704007 @default.
- W3136372277 cites W1618241955 @default.
- W3136372277 cites W1840837207 @default.
- W3136372277 cites W19125392 @default.
- W3136372277 cites W1945972342 @default.
- W3136372277 cites W1964823826 @default.
- W3136372277 cites W1967359088 @default.
- W3136372277 cites W1972859350 @default.
- W3136372277 cites W1976734914 @default.
- W3136372277 cites W1976995612 @default.
- W3136372277 cites W1979059478 @default.
- W3136372277 cites W1988985714 @default.
- W3136372277 cites W1989199118 @default.
- W3136372277 cites W1995380127 @default.
- W3136372277 cites W2007490584 @default.
- W3136372277 cites W2011584482 @default.
- W3136372277 cites W2018521012 @default.
- W3136372277 cites W2030662368 @default.
- W3136372277 cites W2033220022 @default.
- W3136372277 cites W2040030547 @default.
- W3136372277 cites W2051341672 @default.
- W3136372277 cites W2052192720 @default.
- W3136372277 cites W2054344984 @default.
- W3136372277 cites W2059435741 @default.
- W3136372277 cites W2064329260 @default.
- W3136372277 cites W2065072784 @default.
- W3136372277 cites W2072854137 @default.
- W3136372277 cites W2076121010 @default.
- W3136372277 cites W2081544094 @default.
- W3136372277 cites W2084755129 @default.
- W3136372277 cites W2088205785 @default.
- W3136372277 cites W2091537338 @default.
- W3136372277 cites W2100518445 @default.
- W3136372277 cites W2101967682 @default.
- W3136372277 cites W2113219149 @default.
- W3136372277 cites W2121686754 @default.
- W3136372277 cites W2128493116 @default.
- W3136372277 cites W2149045845 @default.
- W3136372277 cites W2154589077 @default.
- W3136372277 cites W2160648230 @default.
- W3136372277 cites W2277351499 @default.
- W3136372277 cites W2322271890 @default.
- W3136372277 cites W2338977631 @default.
- W3136372277 cites W2347077379 @default.
- W3136372277 cites W2396908022 @default.
- W3136372277 cites W2560099569 @default.
- W3136372277 cites W2609951214 @default.
- W3136372277 cites W2741797758 @default.
- W3136372277 cites W2802077859 @default.
- W3136372277 cites W2887161462 @default.
- W3136372277 cites W2903023290 @default.
- W3136372277 cites W2928801673 @default.
- W3136372277 cites W2961959644 @default.
- W3136372277 cites W2967186936 @default.
- W3136372277 cites W3046172755 @default.
- W3136372277 cites W3049123519 @default.
- W3136372277 cites W3049189737 @default.
- W3136372277 cites W3094563030 @default.
- W3136372277 doi "https://doi.org/10.1101/2021.03.12.435085" @default.
- W3136372277 hasPublicationYear "2021" @default.
- W3136372277 type Work @default.
- W3136372277 sameAs 3136372277 @default.
- W3136372277 citedByCount "0" @default.
- W3136372277 crossrefType "posted-content" @default.
- W3136372277 hasAuthorship W3136372277A5002816287 @default.
- W3136372277 hasAuthorship W3136372277A5056874233 @default.
- W3136372277 hasBestOaLocation W31363722771 @default.
- W3136372277 hasConcept C12713177 @default.
- W3136372277 hasConcept C154945302 @default.
- W3136372277 hasConcept C159654299 @default.
- W3136372277 hasConcept C19317047 @default.
- W3136372277 hasConcept C203014093 @default.
- W3136372277 hasConcept C2776090121 @default.
- W3136372277 hasConcept C2778453870 @default.
- W3136372277 hasConcept C2781377902 @default.
- W3136372277 hasConcept C41008148 @default.
- W3136372277 hasConcept C70721500 @default.
- W3136372277 hasConcept C86803240 @default.
- W3136372277 hasConcept C8891405 @default.
- W3136372277 hasConcept C96926380 @default.
- W3136372277 hasConcept C9756297 @default.
- W3136372277 hasConceptScore W3136372277C12713177 @default.
- W3136372277 hasConceptScore W3136372277C154945302 @default.
- W3136372277 hasConceptScore W3136372277C159654299 @default.
- W3136372277 hasConceptScore W3136372277C19317047 @default.
- W3136372277 hasConceptScore W3136372277C203014093 @default.
- W3136372277 hasConceptScore W3136372277C2776090121 @default.
- W3136372277 hasConceptScore W3136372277C2778453870 @default.
- W3136372277 hasConceptScore W3136372277C2781377902 @default.
- W3136372277 hasConceptScore W3136372277C41008148 @default.
- W3136372277 hasConceptScore W3136372277C70721500 @default.
- W3136372277 hasConceptScore W3136372277C86803240 @default.