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• W3136372287 abstract "Abstract Background and Objectives Synovial, clear cell, angiosarcoma, rhabdomyosarcoma, and epithelioid (SCARE) soft tissue sarcoma are at risk for nodal involvement, although the nodal positivity rates and impact on prognostication in clinically node negative patients are not well described. Methods Patients with extremity SCARE sarcoma without clinical nodal involvement undergoing surgical resection in the National Cancer Database (2004–2017) were included. Logistic regression was used to evaluate the likelihood of nodal surgery and nodal positivity. Kaplan–Meier method and Cox regression were used to assess associations of nodal status to overall survival. Results We included 4158 patients, and 669 patients (16%) underwent regional lymph node surgery (RLNS). On multivariable logistic analysis, patients with epithelioid (odds ratio [OR]: 3.77; p < .001) and clear cell (OR: 6.38; p < .001) were most likely to undergo RLNS. Forty‐five patients (7%) had positive nodes. Clear cell sarcoma (14%) and angiosarcoma (13%) had the highest rates of nodal positivity. Patients with positive nodes had reduced 5‐year overall survival, and the stratification was largest in clear cell and angiosarcoma. Conclusion Discordance exists between selection for pathologic nodal evaluation and factors associated with nodal positivity. Clinically node negative patients with clear cell and angiosarcoma should be considered for pathologic nodal evaluation." @default.
• W3136372287 created "2021-03-29" @default.
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• W3136372287 date "2021-03-22" @default.
• W3136372287 modified "2023-10-03" @default.
• W3136372287 title "Pathologic nodal staging for clinically node negative soft tissue sarcoma of the extremities" @default.
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• W3136372287 doi "https://doi.org/10.1002/jso.26465" @default.
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