FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136373351> ?p ?o ?g. }

• W3136373351 endingPage "9692" @default.
• W3136373351 startingPage "9679" @default.
• W3136373351 abstract "AlkB family of Fe (II) and α-ketoglutarate-dependent dioxygenases plays essential roles in development of ovarian serous carcinoma (OV). However, the molecular profiles of AlkB family in OV have not been clarified. The results indicated that the expression of ALKBH1/3/5/8 and FTO was lower in OV patients while ALKBH2/4/6/7 expression was higher. There was a strong correlation between ALKBH5/7 and pathological stage of OV patients. Kaplan-Meier plotter revealed that OV patients with high ALKBH4 level showed longer overall survival (OS). However, patients with high levels of ALKBH5/6 and FTO showed shorter OS and progression-free survival (PFS). Genetic alterations using cBioPortal revealed that the alteration rates of FTO were the highest. We also found that the functions of AlkB family were linked to several cancer-associated signaling pathways, including chemokine receptor signaling. TIMER database indicated that the AlkB family had a strong relationship with the infiltration of six types of immune cells (macrophages, neutrophils, CD8+ T-cells, B-cells, CD4+ T-cells and dendritic cells). Next, DiseaseMeth databases revealed that the global methylation levels of ALKBH1/2/3/4/5/6/7/8 and FTO were all lower in OV patients. Thus, our findings will enhance the understanding of AlkB family in OV pathology, and provide novel insights into AlkB-targeted therapy for OV patients." @default.
• W3136373351 created "2021-03-29" @default.
• W3136373351 creator A5014434687 @default.
• W3136373351 creator A5024999587 @default.
• W3136373351 creator A5042125139 @default.
• W3136373351 creator A5079316394 @default.
• W3136373351 creator A5079406279 @default.
• W3136373351 creator A5083336644 @default.
• W3136373351 creator A5085402375 @default.
• W3136373351 date "2021-03-19" @default.
• W3136373351 modified "2023-10-16" @default.
• W3136373351 title "Expression and molecular profiles of the AlkB family in ovarian serous carcinoma" @default.
• W3136373351 cites W1985213868 @default.
• W3136373351 cites W2012514086 @default.
• W3136373351 cites W2122969281 @default.
• W3136373351 cites W2149441684 @default.
• W3136373351 cites W2557962097 @default.
• W3136373351 cites W2559588208 @default.
• W3136373351 cites W2590497374 @default.
• W3136373351 cites W2600626962 @default.
• W3136373351 cites W2725383737 @default.
• W3136373351 cites W2810425480 @default.
• W3136373351 cites W2829377719 @default.
• W3136373351 cites W2895593282 @default.
• W3136373351 cites W2897805491 @default.
• W3136373351 cites W2898871895 @default.
• W3136373351 cites W2900569176 @default.
• W3136373351 cites W2911349862 @default.
• W3136373351 cites W2917476978 @default.
• W3136373351 cites W2945580636 @default.
• W3136373351 cites W2946173685 @default.
• W3136373351 cites W2946657092 @default.
• W3136373351 cites W2950595506 @default.
• W3136373351 cites W2970534831 @default.
• W3136373351 cites W2971531693 @default.
• W3136373351 cites W2989734860 @default.
• W3136373351 cites W2991462722 @default.
• W3136373351 cites W2992958546 @default.
• W3136373351 cites W3001179989 @default.
• W3136373351 cites W3003715948 @default.
• W3136373351 cites W3008823185 @default.
• W3136373351 cites W3012468089 @default.
• W3136373351 cites W3019748358 @default.
• W3136373351 cites W3025217711 @default.
• W3136373351 cites W3027286012 @default.
• W3136373351 cites W3029082514 @default.
• W3136373351 cites W3031129122 @default.
• W3136373351 cites W3034923646 @default.
• W3136373351 cites W3048545728 @default.
• W3136373351 cites W3048647773 @default.
• W3136373351 cites W3048858129 @default.
• W3136373351 cites W3087357976 @default.
• W3136373351 cites W3089709611 @default.
• W3136373351 cites W3089886777 @default.
• W3136373351 cites W3090749027 @default.
• W3136373351 cites W3093425417 @default.
• W3136373351 cites W3112751811 @default.
• W3136373351 doi "https://doi.org/10.18632/aging.202716" @default.
• W3136373351 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8064172" @default.
• W3136373351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33744868" @default.
• W3136373351 hasPublicationYear "2021" @default.
• W3136373351 type Work @default.
• W3136373351 sameAs 3136373351 @default.
• W3136373351 citedByCount "20" @default.
• W3136373351 countsByYear W31363733512021 @default.
• W3136373351 countsByYear W31363733512022 @default.
• W3136373351 countsByYear W31363733512023 @default.
• W3136373351 crossrefType "journal-article" @default.
• W3136373351 hasAuthorship W3136373351A5014434687 @default.
• W3136373351 hasAuthorship W3136373351A5024999587 @default.
• W3136373351 hasAuthorship W3136373351A5042125139 @default.
• W3136373351 hasAuthorship W3136373351A5079316394 @default.
• W3136373351 hasAuthorship W3136373351A5079406279 @default.
• W3136373351 hasAuthorship W3136373351A5083336644 @default.
• W3136373351 hasAuthorship W3136373351A5085402375 @default.
• W3136373351 hasBestOaLocation W31363733511 @default.
• W3136373351 hasConcept C104317684 @default.
• W3136373351 hasConcept C121608353 @default.
• W3136373351 hasConcept C126322002 @default.
• W3136373351 hasConcept C134935766 @default.
• W3136373351 hasConcept C143998085 @default.
• W3136373351 hasConcept C150173356 @default.
• W3136373351 hasConcept C2777546739 @default.
• W3136373351 hasConcept C2777721518 @default.
• W3136373351 hasConcept C2780427987 @default.
• W3136373351 hasConcept C3019054536 @default.
• W3136373351 hasConcept C502942594 @default.
• W3136373351 hasConcept C54355233 @default.
• W3136373351 hasConcept C71924100 @default.
• W3136373351 hasConcept C86803240 @default.
• W3136373351 hasConceptScore W3136373351C104317684 @default.
• W3136373351 hasConceptScore W3136373351C121608353 @default.
• W3136373351 hasConceptScore W3136373351C126322002 @default.
• W3136373351 hasConceptScore W3136373351C134935766 @default.
• W3136373351 hasConceptScore W3136373351C143998085 @default.
• W3136373351 hasConceptScore W3136373351C150173356 @default.
• W3136373351 hasConceptScore W3136373351C2777546739 @default.
• W3136373351 hasConceptScore W3136373351C2777721518 @default.

• next