Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136374593> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W3136374593 endingPage "1409" @default.
- W3136374593 startingPage "1398" @default.
- W3136374593 abstract "The arginine-glutamic acid dipeptide repeats gene (RERE) encodes a nuclear receptor coregulator that modulates gene expression through its interaction with transcriptional machinery. In humans, RERE deficiency causes neurodevelopmental disorder with or without structural defects of the brain, eye, heart, and kidney (NEDBEH). Ophthalmological defects are seen in approximately one third of individuals with NEDBEH and in RERE-deficient mice which can serve as a useful animal model.In mice, RERE is expressed in a subset of retinal ganglion cells (RGC), the lens epithelium, and the ciliary body during the embryonic period. RERE expression expands into the outer nuclear layer and the inner nuclear layer during the postnatal period. RERE-deficient mice have retinal and optic nerve atrophy. We show that RERE deficiency causes progressive loss of retinal cells and apoptosis of retinal cells in the ganglion cell layer as early as E17.5. The number of RGCs is also reduced in RERE-deficient embryos and mice.We conclude that RERE is required to control the apoptosis of retinal cells in the developing retina, and that RERE deficiency results in the retina atrophy through degeneration of the retinal cells and optic nerve atrophy through the loss of RGCs." @default.
- W3136374593 created "2021-03-29" @default.
- W3136374593 creator A5033087588 @default.
- W3136374593 creator A5085873463 @default.
- W3136374593 date "2021-03-29" @default.
- W3136374593 modified "2023-09-25" @default.
- W3136374593 title "<scp>RERE</scp> deficiency causes retinal and optic nerve atrophy through degeneration of retinal cells" @default.
- W3136374593 cites W1834486239 @default.
- W3136374593 cites W1967234593 @default.
- W3136374593 cites W2013851169 @default.
- W3136374593 cites W2019071873 @default.
- W3136374593 cites W2033029606 @default.
- W3136374593 cites W2034018159 @default.
- W3136374593 cites W2041598409 @default.
- W3136374593 cites W2059679976 @default.
- W3136374593 cites W2066556283 @default.
- W3136374593 cites W2068143304 @default.
- W3136374593 cites W2068786255 @default.
- W3136374593 cites W2070205880 @default.
- W3136374593 cites W2108015718 @default.
- W3136374593 cites W2136262485 @default.
- W3136374593 cites W2154653170 @default.
- W3136374593 cites W2163595334 @default.
- W3136374593 cites W2301539943 @default.
- W3136374593 cites W2340147577 @default.
- W3136374593 cites W2783930882 @default.
- W3136374593 cites W2883197460 @default.
- W3136374593 cites W4245688412 @default.
- W3136374593 doi "https://doi.org/10.1002/dvdy.330" @default.
- W3136374593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33742727" @default.
- W3136374593 hasPublicationYear "2021" @default.
- W3136374593 type Work @default.
- W3136374593 sameAs 3136374593 @default.
- W3136374593 citedByCount "1" @default.
- W3136374593 countsByYear W31363745932022 @default.
- W3136374593 crossrefType "journal-article" @default.
- W3136374593 hasAuthorship W3136374593A5033087588 @default.
- W3136374593 hasAuthorship W3136374593A5085873463 @default.
- W3136374593 hasBestOaLocation W31363745931 @default.
- W3136374593 hasConcept C105702510 @default.
- W3136374593 hasConcept C142724271 @default.
- W3136374593 hasConcept C169760540 @default.
- W3136374593 hasConcept C2777093970 @default.
- W3136374593 hasConcept C2777506830 @default.
- W3136374593 hasConcept C2778231335 @default.
- W3136374593 hasConcept C2780188069 @default.
- W3136374593 hasConcept C2780827179 @default.
- W3136374593 hasConcept C2780837183 @default.
- W3136374593 hasConcept C2781040256 @default.
- W3136374593 hasConcept C2781172350 @default.
- W3136374593 hasConcept C54355233 @default.
- W3136374593 hasConcept C55493867 @default.
- W3136374593 hasConcept C71924100 @default.
- W3136374593 hasConcept C86803240 @default.
- W3136374593 hasConcept C95444343 @default.
- W3136374593 hasConceptScore W3136374593C105702510 @default.
- W3136374593 hasConceptScore W3136374593C142724271 @default.
- W3136374593 hasConceptScore W3136374593C169760540 @default.
- W3136374593 hasConceptScore W3136374593C2777093970 @default.
- W3136374593 hasConceptScore W3136374593C2777506830 @default.
- W3136374593 hasConceptScore W3136374593C2778231335 @default.
- W3136374593 hasConceptScore W3136374593C2780188069 @default.
- W3136374593 hasConceptScore W3136374593C2780827179 @default.
- W3136374593 hasConceptScore W3136374593C2780837183 @default.
- W3136374593 hasConceptScore W3136374593C2781040256 @default.
- W3136374593 hasConceptScore W3136374593C2781172350 @default.
- W3136374593 hasConceptScore W3136374593C54355233 @default.
- W3136374593 hasConceptScore W3136374593C55493867 @default.
- W3136374593 hasConceptScore W3136374593C71924100 @default.
- W3136374593 hasConceptScore W3136374593C86803240 @default.
- W3136374593 hasConceptScore W3136374593C95444343 @default.
- W3136374593 hasIssue "10" @default.
- W3136374593 hasLocation W31363745931 @default.
- W3136374593 hasLocation W31363745932 @default.
- W3136374593 hasOpenAccess W3136374593 @default.
- W3136374593 hasPrimaryLocation W31363745931 @default.
- W3136374593 hasRelatedWork W1580111767 @default.
- W3136374593 hasRelatedWork W1825190414 @default.
- W3136374593 hasRelatedWork W1984590906 @default.
- W3136374593 hasRelatedWork W1999442133 @default.
- W3136374593 hasRelatedWork W2040586345 @default.
- W3136374593 hasRelatedWork W2105626472 @default.
- W3136374593 hasRelatedWork W2168408556 @default.
- W3136374593 hasRelatedWork W2375508316 @default.
- W3136374593 hasRelatedWork W2797499545 @default.
- W3136374593 hasRelatedWork W3037685433 @default.
- W3136374593 hasVolume "250" @default.
- W3136374593 isParatext "false" @default.
- W3136374593 isRetracted "false" @default.
- W3136374593 magId "3136374593" @default.
- W3136374593 workType "article" @default.