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- W3136384471 abstract "A forward genetic screening approach identified orf19.2500 as a gene controlling Candida albicans biofilm dispersal and biofilm detachment. Three-dimensional (3D) protein modeling and bioinformatics revealed that orf19.2500 is a conserved mitochondrial protein, structurally similar to, but functionally diverged from, the squalene/phytoene synthases family. The C . albicans orf19.2500 is distinguished by 3 evolutionarily acquired stretches of amino acid inserts, absent from all other eukaryotes except a small number of ascomycete fungi. Biochemical assays showed that orf19.2500 is required for the assembly and activity of the N A D H u biquinone oxidoreductase Complex I (CI) of the respiratory electron transport chain (ETC) and was thereby named NDU1 . NDU1 is essential for respiration and growth on alternative carbon sources, important for immune evasion, required for virulence in a mouse model of hematogenously disseminated candidiasis, and for potentiating resistance to antifungal drugs. Our study is the first report on a protein that sets the Candida -like fungi phylogenetically apart from all other eukaryotes, based solely on evolutionary “gain” of new amino acid inserts that are also the functional hub of the protein." @default.
- W3136384471 created "2021-03-29" @default.
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- W3136384471 date "2021-03-15" @default.
- W3136384471 modified "2023-10-12" @default.
- W3136384471 title "An evolutionarily diverged mitochondrial protein controls biofilm growth and virulence in Candida albicans" @default.
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- W3136384471 doi "https://doi.org/10.1371/journal.pbio.3000957" @default.
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