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- W3136390274 abstract "• Synthesis, characterization of zinc(II) with Schiff base complex. • Crystal structure of zinc(II) complex. • DNA binding studies by electronic absorption and luminescence titrations. • Biological study in anti-lung cancer activity. Schiff base 3,5-dibromo- N -(8-quinolyl)salicylaldimine (HqsalBr 2 ) and its zinc(II) complex, [Zn(qsalBr 2 ) 2 ], have been synthesized and characterized using spectroscopic techniques and single crystal X-Ray crystallography. The interaction of the complex with calf thymus DNA (CT-DNA) was investigated by electronic absorption and luminescence titration methods. The results reveal the intercalative mode of binding between the synthesized complex and CT-DNA with binding constant (K b ) of 2.00 × 10 6 M −1 . The complex also exhibits capability in the competitive reaction with the standard ethidium bromide (EB) and provides favourable quenching constant value (K q ) of 7.91 × 10 11 M −1 s −1 . Anti-lung cancer activity against A549 cell line was examined and zinc(II) complex performed the ability in the inhibition of this cancer cell growing." @default.
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- W3136390274 date "2021-06-01" @default.
- W3136390274 modified "2023-09-24" @default.
- W3136390274 title "The novel zinc(II) complex with dibromo substituted Schiff base and its biological activity" @default.
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- W3136390274 doi "https://doi.org/10.1016/j.matlet.2021.129749" @default.
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